Contrast enhanced ultrasound in diagnosis of endometrial carcinoma and endometrial hyperplasia

Abstract

The present study was aimed to compare application of contrast enhanced ultrasound (CEUS) in diagnosis of endometrial carcinoma (EC) and endometrial hyperplasia (EH). A total of 81 patients with EC and simple EH were selected in this study. Among all patients, 39 cases were diagnosed as EC and 42 cases were diagnosed with EH. All patients were diagnosed by CEUS examination. The diagnosis of EC and EH was also confirmed by endometrial biopsy. CEUS was conducted for all patients. Eendometrial thickness was measured and the mean arrival time, time-to-peak, enhancement time, arrival intensity, peak intensity, enhancement intensity, rising rate, washout half-time and clearance half-time were recorded. Myometrial invasion was categorized into 2 stages <50% and >50%. No significant difference was observed in clinical basis between the two groups. Endometrial thickness of EC was significantly higher than that of EH, P<0.05. Results of CEUS parameters showed that in EC patients, all values of arrival time, time-to-peak, washout half-time and clearance half-time were all shorter in EC group compared with those in EH patients, P<0.05. And values of peak intensity, enhancement intensity, and rising rate were also lower in EC patients than those in EH patients, P<0.05. Diagnostic accuracy of CEUS in myometrial invasion for EC was shown showed that 26 of 30 cases were diagnosed as myometrial invasion <50% by CEUS and 7 of 9 cases were diagnosed as myometrial invasion >50%. The total diagnostic accuracy of CEUS is 82.62% (33/39). We conducted a comparison study to analyze different diagnostic effects of CEUS for EC and EH. The study may give more clinical basic data in the field of CEUS application in diagnosis of EC and can give a reference to the difference between EC and EH.

Contrast-Enhanced Ultrasound Imaging of Uterine Disorders: A Systematic Review

“…Endometrial carcinoma is the most common gynecological malignancy. 18 This is reflected in the higher number of studies evaluating CEUS for this malignancy: one case-control 17 and seven prospective cohort studies, 18,[20][21][22][23][24][25] with histology-proven endometrial carcinoma. These studies did show different enhancement patterns between malignant and healthy tissue.…”

“…The average accuracy of CEUS as diagnostic tool for staging endometrial carcinoma is 81%, with an average sensitivity of 0.78 and specificity of 0.81. 17,18,[20][21][22][23][24][25] The numbers of the individual studies are shown in Table 3. The additional value of combined 2D-and 3D-CEUS imaging (diagnostic accuracy 84%) over 2D-CEUS alone (diagnostic accuracy 75%) was demonstrated in 68 patients with clinically suspected endometrial carcinoma, of which 26 cases were confirmed by histology.…”

Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma

“…The diagnosis of EC thus mainly depends on imaging, immunohistochemistry, pathology, and hysteroscopy [ 9 – 12 ]. At present, it is considered that transvaginal ultrasound measurement of endometrial thickness [ 9 , 13 , 14 ] and endometrial aspiration cytological examination are feasible technologies for EC screening. Dilatation and curettage [ 15 , 16 ] and hysteroscopy are also potentially effective screening methods, but are highly invasive and therefore not recommended.…”

Construction and Comprehensive Analysis of the Competing Endogenous Rna Network in Endometrial Adenocarcinoma

“…The diagnosis of EC thus mainly depends on imaging, immunohistochemistry, pathology, and hysteroscopy [6,[14][15][16]. At present, it is considered that transvaginal ultrasound measurement of endometrial thickness [6][7][8] and endometrial aspiration cytological examination are feasible technologies for EC screening. Dilatation and curettage [9,10] and hysteroscopy are also potentially effective screening methods, but are highly invasive and therefore not recommended.…”