Contrast-Enhanced Ultrasound-Guided Fine-Needle Aspiration for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer

Zhong, Jieyu; Sun, Desheng; Wei, Wei; Liu, Xiaoling; Li, Jun; Wu, Xiaoqin; Zhang, Yusen; Luo, Haiyu; Li, Yongbin

doi:10.1016/j.ultrasmedbio.2018.03.005

Cited by 27 publications

(25 citation statements)

References 35 publications

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“…Some studies showed that CEUS can further improve identification of SLN and reduce SLNB surgical trauma [23][24][25][26]. However, some studies suggested that the false negative rate of SLNB guided by CEUS alone is high and the diagnostic accuracy is low [27,28]. Since the difference in accuracy of assessing axillary status between CEUS-guided SLNB and conventional SLNB is not clear, this meta-analysis reviews the reported studies focusing on SLNB guided by CEUS, further analyzes the difference in the positive rate between SLNs identified by CEUS and SLNs identified not by CEUS, and also analyzes the accuracy of SLN identified by CEUS in diagnosing the pathological status of overall axillary sentinel nodes, in order to explore whether CEUS can further improve the accuracy of sentinel lymph node biopsy.…”

Section: Ultrasonography and Contrast-enhanced Ultrasoundmentioning

confidence: 99%

“…Of the 16 selected studies, 9 used SonoVue as CEUS material [26][27][28][39][40][41][42][43][44], 6 used Sonazoid [23][24][25][45][46][47], and 1 used DEFINITY [48]. The administration sites and methods of contrast agents mainly include intradermal [23-28, 39-44, 47] and subcutaneous [45,46] injection around areola or peritumoral parenchyma injection approaching the axilla [48].…”

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

“…The administration sites and methods of contrast agents mainly include intradermal [23-28, 39-44, 47] and subcutaneous [45,46] injection around areola or peritumoral parenchyma injection approaching the axilla [48]. SLN localization methods are diversified, including skin labeling [23,27,41,42,[44][45][46][47], guidewire localization [25,26,40,43,48], labeled peptide clip localization [28], iodine-125 seed implantation [39], and ultrasound-guided fluorescent dye injection [24]. Seven studies used the isotope-dye dual tracer method as a comparator [23,27,39,43,45,46,48], while another nine studies were compared with the simple dye method [24-26, 28, 40-42, 44, 47].…”

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

“…SLN localization methods are diversified, including skin labeling [23,27,41,42,[44][45][46][47], guidewire localization [25,26,40,43,48], labeled peptide clip localization [28], iodine-125 seed implantation [39], and ultrasound-guided fluorescent dye injection [24]. Seven studies used the isotope-dye dual tracer method as a comparator [23,27,39,43,45,46,48], while another nine studies were compared with the simple dye method [24-26, 28, 40-42, 44, 47]. Sixteen studies showed that the detection rate of SLN by CEUS method was 70~100% [23][24][25][26][27][28][39][40][41][42][43][44][45][46][47][48], as shown in Fig.…”

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

“…Seven studies used the isotope-dye dual tracer method as a comparator [23,27,39,43,45,46,48], while another nine studies were compared with the simple dye method [24-26, 28, 40-42, 44, 47]. Sixteen studies showed that the detection rate of SLN by CEUS method was 70~100% [23][24][25][26][27][28][39][40][41][42][43][44][45][46][47][48], as shown in Fig. 2.…”

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

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Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis

Cui

et al. 2020

World J Surg Onc

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Objective: To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB). Method: Collect published literatures or conference reports by searching electronic databases. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) evaluation method is used to evaluate the quality of the screened literatures. The pooled risk ratio of cancer metastasis of SLN identified by CEUS (CE-SLN) compared with SLN not identified by CEUS (nonCE-SLN) is calculated, and the pooled diagnostic accuracy of CE-SLN for pathological status of all SLNs is also evaluated. Result: Through search and screening, a total of 16 studies were included, of which five and seven studies, respectively, entered the meta-analysis of metastatic risk ratio and diagnostic accuracy. The localization rate of preoperative CEUS for sentinel lymph nodes was 70 to 100%. The meta-analysis shows that the risk of metastasis of SLN identified by CEUS is significantly higher than that not identified by CEUS, 26.0% vs 4.6%, and risk ratio (RR) is 6.08 (95% CI 4.17-8.85). In early-stage breast cancer, the pathological status of CE-SLN is a good representative of all SLNs, with a pooled sensitivity of 98% (95% CI 0.94-1.00), pooled specificity of 100% (95% CI 0.99-1.00), diagnostic odds ratio (DOR) of 2153.18 (95% CI 476.53-9729.06), and area under the subject receiver operating characteristic (SROC) curve of 0.9968. Conclusion: In early-stage breast cancer, preoperative localization of SLN by CEUS is expected to further improve the accuracy of sentinel lymph node biopsy (SLNB).

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Section: Ultrasonography and Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

Section: The Localization Detection Rate Of Ceus For Slnmentioning

confidence: 99%

See 3 more Smart Citations

Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis

Cui

et al. 2020

World J Surg Onc

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Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Kurochkin

German

Abalymov

et al. 2021

Journal of Biophotonics

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The status of sentinel lymph nodes (SLNs) has a substantial prognostic value because these nodes are the first place where cancer cells accumulate along their spreading route. Routine SLN biopsy ("gold standard") involves peritumoral injections of radiopharmaceuticals, such as technetium-99m, which has obvious disadvantages. This review examines the methods used as "gold standard" analogs to diagnose SLNs. Nonradioactive preoperative and intraoperative methods of SLN detection are analyzed. Promising photonic tools for SLNs detection are reviewed, including NIR-I/NIR-II fluorescence imaging, photoswitching dyes for SLN detection, in vivo photoacoustic detection, imaging and biopsy of SLNs. Also are discussed methods of SLN detection by magnetic resonance imaging, ultrasonic imaging systems including as combined with photoacoustic imaging, and methods based on the magnetometer-aided detection of superparamagnetic nanoparticles. The advantages and disadvantages of nonradioactive SLN-detection methods are shown. The review concludes with prospects for the use of conservative diagnostic methods in combination with photonic tools.

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Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography

Machado

Liu

Needleman

et al. 2023

J of Ultrasound Medicine

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Objectives This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical excision. Methods Seventy‐nine subjects scheduled for breast cancer surgery with SLN excision completed this IRB‐approved study, out of which 18 (23%) underwent neoadjuvant chemotherapy before surgery. Subjects underwent percutaneous Sonazoid (GE Healthcare) injections around the tumor area for a total of 1.0 mL. Lymphosonography was performed using CPS on an S3000 HELX scanner (Siemens Healthineers) with a linear probe. Subjects received blue dye and radioactive tracer as part of their standard of care. Excised SLNs were classified as positive or negative for the presence of blue dye, radioactive tracer and Sonazoid. The results were compared between methods and pathology findings. Results Seventy‐two SLNs were surgically excised from 18 subjects, 29 were positive for blue dye, 63 were positive for radioactive tracer and 57 were positive for Sonazoid. Comparison with blue dye showed that both radioactive tracer and lymphosonography achieved an accuracy of 53% (P > .50). Comparison with radioactive tracer showed that blue dye had an accuracy of 53%, while lymphosonography achieved an accuracy of 67% (P < .01). Of the 72 SLNs, 15 were determined malignant by pathology; the detection rate was 47% for blue dye (7/15), 67% for radioactive tracer (10/15) and 100% for lymphosonography (15/15) (P < .001). Conclusions Lymphosonography achieved similar accuracy as radioactive tracer and higher accuracy than blue dye for identifying SLNs. The 15 SLNs positive for malignancy were all identified by lymphosonography.

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Contrast-Enhanced Ultrasound-Guided Fine-Needle Aspiration for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer

Cited by 27 publications

References 35 publications

Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis

Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography

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