Contrast-enhanced Ultrasound for Detection of Crohn’s Disease Activity: Systematic Review and Meta-analysis

Serafin, Zbigniew; Białecki, Marcin; Białecka, Agnieszka; Sconfienza, Luca Maria; Kłopocka, Maria

doi:10.1093/ecco-jcc/jjv196

Cited by 70 publications

(49 citation statements)

References 46 publications

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“…CEUS can also be used to assess postoperative recurrence of Crohn's disease [199]. Two meta-analyses concluded that CEUS in the assessment of IBD activity is accurate and a highly sensitive and specific method [200,201].…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

et al. 2018

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Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

et al. 2018

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“…Pallotta et al [19] demonstrated improved sensitivity (96-100% vs. 75-76%) while maintaining 100% specificity of small intestinal contrast US compared to conventional transabdominal US. Few studies have been conducted on the use of contrast-enhanced US for Crohn disease, of which both adult and pediatric populations were included [23,24]. A metaanalysis demonstrated pooled sensitivity of 94% (95% CI: 87-97%) and pooled specificity of 79% (95% CI: 67-88%) [24].…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have been conducted on the use of contrast-enhanced US for Crohn disease, of which both adult and pediatric populations were included [23,24]. A metaanalysis demonstrated pooled sensitivity of 94% (95% CI: 87-97%) and pooled specificity of 79% (95% CI: 67-88%) [24]. This technique allows for improved detection and analysis of bowel perfusion and may prove to increase US accuracy.…”

Section: Discussionmentioning

confidence: 99%

Can ultrasound be used as the primary imaging in children with suspected Crohn disease?

et al. 2017

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“…Also, it is effective in distinguishing inflammatory from fibrostenotic lesions, so it can provide prognostic information and guide further management [78,79]. However, its importance regarding IBD is still unclear, and more research is needed [80,81].…”

Section: Monitoringmentioning

confidence: 99%

The importance of intestinal ultrasound and elastographic techniques in inflammatory bowel diseases

Marin

Tribus

Fierbinţeanu-Braticevici

2018

Med Ultrason

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Inflammatory bowel diseases have an important impact upon the economic and social status due to their increasing incidence and prevalence, often affecting young people. At the moment, the therapeutic goal goes beyond the improvement of symptoms and laboratory parameters, being represented by endoscopic mucosal healing, changing the disease’s natural history. Even though endoscopy is the gold standard for the assessment of mucosal healing, it is an invasive maneuver and it lacks good repeatability. These patients require frequent evaluation; therefore, interest for noninvasive techniques has risen.As a consequence, the importance of intestinal ultrasound has increased lately and recent studies support its use to assess the degree of inflammation, to differentiate between remission and relapse, to monitor therapy response and guide treatment, to evaluate prognosis, and to diagnose complications. Another promising noninvasive imagistic technique is elastography which has gained interest because of its capacity to discriminate between inflammatory and fibrotic tissue, taking into account the different therapeutic options for the fibrotic strictures compared to inflammatory processes. This review summarizes the actual recommendations regarding the use of intestinal ultrasound and elastographic techniques for the diagnosis and monitoring of inflammatory bowel diseases.

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Contrast-enhanced Ultrasound for Detection of Crohn’s Disease Activity: Systematic Review and Meta-analysis

Abstract: CEUS presents good sensitivity and moderate specificity in the detection of the aCD. Large-scale randomized trials with quantitative evaluation of CEUS images are necessary to promote this technique in clinical practice.

Cited by 70 publications

References 46 publications

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

Can ultrasound be used as the primary imaging in children with suspected Crohn disease?

The importance of intestinal ultrasound and elastographic techniques in inflammatory bowel diseases

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