Contrast-enhanced ultrasonography for the diagnosis of spontaneous necrosis of hepatocellular carcinoma: A report of 2 cases

Ota, Yu; Aso, Kazunobu; Otake, Shin; Okada, Masaya; Shukuda, Kounosuke; Sawada, Koji; Yokoo, Hideki; Tanino, Mishie; Fujiya, Mikihiro; Okumura, Toshikatsu

doi:10.1016/j.radcr.2022.10.019

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…The use of CEUS for evaluating focal liver lesions is recommended by the American Association for the Study of Liver Diseases (9) and the European Association for the Study of the Liver (19). Recently, we reported that CEUS is useful for the diagnosis of spontaneous necrosis in HCC, which is generally difficult to identify (20). CEUS can be used to assess necrosis in HCC with greater sensitivity than CT or magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced Ultrasonography Features for Diagnosing Pseudoprogression of Hepatocellular Carcinoma with Immunotherapy: A Case Report of the Response after Pseudoprogression

Otake,

Ota,

Aso

et al. 2024

Intern. Med.

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A male patient in his 70s with recurrent hepatocellular carcinoma (HCC) after surgery received atezolizumab plus bevacizumab (Atezo+Bev) therapy. Initial computed tomography (CT) revealed tumor growth along with an increase in tumor markers, and contrast-enhanced ultrasonography (CEUS) showed multiple round avascular areas within the nodules with an appearance similar to a slice of Swiss cheese. Continuation of immunotherapy with consideration of the potential for pseudoprogression produced a dramatic response. Although it is difficult to distinguish between true progression and pseudoprogression, the Swiss cheese-like appearance on CEUS may be important for the early diagnosis of pseudoprogression.

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Section: Discussionmentioning

confidence: 99%

Contrast-enhanced Ultrasonography Features for Diagnosing Pseudoprogression of Hepatocellular Carcinoma with Immunotherapy: A Case Report of the Response after Pseudoprogression

Otake,

Ota,

Aso

et al. 2024

Intern. Med.

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“…The use of CEUS for evaluation of focal liver lesions is recommended by the American Association for the Study of Liver Diseases [14] and the European Association for the Study of the Liver [15]. We recently reported that CEUS is useful for diagnosing spontaneous necrosis in HCC, which is generally difficult to identify [16]. Additionally, we reported that CEUS can help to distinguish pseudoprogression from true progression of immunotherapytreated HCC [17].…”

mentioning

confidence: 99%

Noninvasive Visualization of Tumor Blood Vessels within Hepatocellular Carcinoma by Application of Superb Microvascular Imaging to Contrast-Enhanced Ultrasonography

Ota,

Aso,

Yokoo

et al. 2024

Diagnostics

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The combination or sequential use of systemic therapies, such as lenvatinib and locoregional therapies, can improve the curability rate of hepatocellular carcinoma. This is based on the notion that lenvatinib remodels abnormal tumor vessels into normal vessels, potentially enhancing the efficacy of locoregional therapies. In this case report, we achieved noninvasive visualization of tumor blood vessels by applying superb microvascular imaging (SMI) to contrast-enhanced ultrasonography (CEUS). A man in his 80s with a borderline resectable hepatocellular carcinoma received preoperative therapy using lenvatinib. The patient achieved a complete response after lenvatinib therapy, underwent hepatectomy, and maintained a cancer-free status. CEUS and SMI revealed a decrease in tumor blood vessels at 1 week after lenvatinib administration and a decrease in tumor perfusion at 2 weeks. Although CEUS alone is adequate for noninvasive real-time evaluation of tumor perfusion, it is not sufficient to achieve accurate assessments of tumor blood vessels. We performed a noninvasive time-course evaluation of vascular normalization after lenvatinib administration by applying SMI. The evaluation of vascular normalization with lenvatinib therapy using CEUS and SMI can support the decision to proceed to conversion therapies.

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Contrast-enhanced ultrasonography for the diagnosis of spontaneous necrosis of hepatocellular carcinoma: A report of 2 cases

Cited by 2 publications

References 16 publications

Contrast-enhanced Ultrasonography Features for Diagnosing Pseudoprogression of Hepatocellular Carcinoma with Immunotherapy: A Case Report of the Response after Pseudoprogression

Contrast-enhanced Ultrasonography Features for Diagnosing Pseudoprogression of Hepatocellular Carcinoma with Immunotherapy: A Case Report of the Response after Pseudoprogression

Noninvasive Visualization of Tumor Blood Vessels within Hepatocellular Carcinoma by Application of Superb Microvascular Imaging to Contrast-Enhanced Ultrasonography

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