Contrast-enhanced multi-shot echo-planar FLAIR in the depiction of metastatic tumors of the brain: comparison with contrast-enhanced spin-echo T1-weighted imaging

Tomura, Noriaki; Narita, Komei; Takahashi, Satoshi; Sakuma, Ikuo; Yasuda, K.; Nishii, Toshiaki; Watarai, Jiro

doi:10.1080/02841850701499425

Cited by 18 publications

(12 citation statements)

References 22 publications

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“…2), can suggest the underlying primary lesion. The utilization of alternative conventional sequences such as contrast-enhanced multi-shot echo planar fluid attenuated inversion recovery (FLAIR) [ 12 ] and pre- and post-contrast inversion recovery T1-weighted sequences [ 13 ] instead of conventional T1 spin echo sequences have failed to demonstrate benefit in improving lesion conspicuity. Phenotypic descriptors such as non-enhancing cortical FLAIR signal abnormality adjacent to the mass lesion have been described more frequently in glioma but this feature is also seen in some cases of cerebral metastases [ 14 ] .…”

Section: Conventional Imagingmentioning

confidence: 99%

Advanced magnetic resonance imaging biomarkers of cerebral metastases

2012

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There are a number of magnetic resonance imaging techniques available for use in the diagnosis and management of patients with cerebral metastases. This article reviews these techniques, in particular, the advanced imaging methodologies from which quantitative parameters can be derived, the role of these imaging biomarkers have in distinguishing metastases from primary central nervous system tumours and tumour mimics, and metrics that may be of value in predicting the origin of the primary tumour.

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Section: Conventional Imagingmentioning

confidence: 99%

Advanced magnetic resonance imaging biomarkers of cerebral metastases

2012

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“…Several previous studies proved that SD Gd-enhanced fluid-attenuated inversion recovery (FLAIR) is useful in the evaluation of superficial metastases and leptomeningeal metastases, because this sequence does not lead to contrast enhancement of vessels 8,9,10,11. However, the optimal dose of Gd to maximize the detection of metastases on Gd-enhanced FLAIR is undetermined, and unlike T1 weighted images, FLAIR with higher dose of Gd might not provide high diagnostic yield in the detection of brain metastases, because an increase in the T2 effect obscures the enhancing T1 effect 8,12.…”

Section: Introductionmentioning

confidence: 99%

The Added Value of Double Dose Gadolinium Enhanced 3D T2 Fluid-Attenuated Inversion Recovery for Evaluating Small Brain Metastases

et al. 2014

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PurposeSingle dose gadolinium (Gd) enhanced fluid-attenuated inversion recovery (FLAIR) is helpful for visualizing superficial parenchymal metastases. However, the usefulness of FLAIR with a higher dose of Gd is uncertain. The aim of our study was two-folds: first, to prove that the signal to noise ratio (SNR) of small brain metastases is higher than large brain metastases on double-dose (DD) enhanced FLAIR and, second, to explore the added value of DD Gd enhanced FLAIR in relation to T1 GRE for evaluating small brain metastases.Materials and MethodsFor the first purpose, 50 pairs of small (2 mm5 mm) were included. The difference in the SNR and contrast ratio (CR) between small and large metastases on DD Gd-enhanced 3D T2 FLAIR was compared by Wilcoxon signed-rank tests. For the second purpose, a total of 404 small metastases were included. The diagnostic sensitivities between 3D T1 gradient echo (GRE) alone and combined results of 3D T1 GRE and 3D T2 FLAIR were compared with McNemar test.ResultsThe SNR and CR of small brain metastases were significantly higher than those of large brain metastases (p<0.001). In qualitative analysis, the diagnostic sensitivities for small brain metastases were significantly higher for 3D T1 GRE plus 3D T2 FLAIR than 3D T1 GRE alone regardless of scan time (p<0.001).ConclusionSmall brain metastases showed higher signal intensity than large brain metastases on the DD Gd enhanced 3D T2 FLAIR images. DD Gd enhanced 3D T2 FLAIR imaging may have a complementary role to 3D T1 GRE for evaluating small brain metastases.

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“…Acquisitions of 3D T 1 -weighted images with minimized susceptibility-induced decays benefit MRI scans, providing thin contiguous slices without cross-talks and unambiguous spatially specific positive contrast for in vivo applications with easier manipulation of resolution and signal to noise ratio (SNR)12345678. One of major drawbacks in acquiring such 3D volumetric images is the extended scan times from the multiple repetitions that are necessary to cover the increased number of phase-encodings for 3D k -space acquisition9.…”

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confidence: 99%

Ultrafast 3D spin-echo acquisition improves Gadolinium-enhanced MRI signal contrast enhancement

Han

Cho

Song

et al. 2014

Sci Rep

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Long scan times of 3D volumetric MR acquisitions usually necessitate ultrafast in vivo gradient-echo acquisitions, which are intrinsically susceptible to magnetic field inhomogeneities. This is especially problematic for contrast-enhanced (CE)-MRI applications, where non-negligible T2* effect of contrast agent deteriorates the positive signal contrast and limits the available range of MR acquisition parameters and injection doses. To overcome these shortcomings without degrading temporal resolution, ultrafast spin-echo acquisitions were implemented. Specifically, a multiplicative acceleration factor from multiple spin echoes (×32) and compressed sensing (CS) sampling (×8) allowed highly-accelerated 3D Multiple-Modulation-Multiple-Echo (MMME) acquisition. At the same time, the CE-MRI of kidney with Gd-DOTA showed significantly improved signal enhancement for CS-MMME acquisitions (×7) over that of corresponding FLASH acquisitions (×2). Increased positive contrast enhancement and highly accelerated acquisition of extended volume with reduced RF irradiations will be beneficial for oncological and nephrological applications, in which the accurate in vivo 3D quantification of contrast agent concentration is necessary with high temporal resolution.

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Contrast-enhanced multi-shot echo-planar FLAIR in the depiction of metastatic tumors of the brain: comparison with contrast-enhanced spin-echo T1-weighted imaging

Abstract: Detectability of brain metastases with Ms-EPI-FLAIR (+) is almost similar to that with SE-T1WI (+). Ms-EPI-FLAIR (+) could be an alternative to SE-T1WI (+) in the depiction of brain metastases.

Cited by 18 publications

References 22 publications

Advanced magnetic resonance imaging biomarkers of cerebral metastases

Advanced magnetic resonance imaging biomarkers of cerebral metastases

The Added Value of Double Dose Gadolinium Enhanced 3D T2 Fluid-Attenuated Inversion Recovery for Evaluating Small Brain Metastases

Ultrafast 3D spin-echo acquisition improves Gadolinium-enhanced MRI signal contrast enhancement

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