Contrast-enhanced magnetisation transfer MRI in metastatic lesions of the brain

Peretti-Viton, P.; Taïeb, David; Viton, Jean-Michel; Flori, A; Muracciole, Xavier; Benguigui, V.; Salamon, G

doi:10.1007/s002340050684

Cited by 20 publications

(8 citation statements)

References 20 publications

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“…Although magnetization transfer (MT) techniques [26,27] were not employed in this study, future work might usefully be aimed at assessing the bene®ts of combining this technique with the use of low dose (0.05 mmol/kg) gadobenate dimeglumine. In this regard, a recent study on a mixed lesion population has suggested that T1wSE imaging with MT and 0.05 mmol/kg of a conventional gadolinium agent can replace standard dose T1wSE imaging without MT, at least for the imaging of meningioma [28].…”

Section: Discussionmentioning

confidence: 98%

Magnetic resonance imaging of metastatic disease to the brain with gadobenate dimeglumine

Balériaux

Colosimo

Ruscalleda³

et al. 2002

Neuroradiology

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Seventy-four patients with one to eight proven intraaxial brain metastases received a total cumulative dose of 0.2 mmol/kg bodyweight gadobenate dimeglumine, administered as sequential injections of 0.05, 0.05 and 0.1 m mol/kg over a 20-min period. MR imaging was performed before the first administration (T2- and T1-weighted sequences) and after each injection of contrast agent (T1-weighted sequences only). Quantitative assessment of images revealed significant (P <0.01) dose-related increases in lesion-to-brain (L/B) ratio and percent enhancement of lesion signal intensity. Qualitative assessment by two independent, blinded assessors revealed additional lesions in 22%, 25% and 38% (assessor 1) and 29%, 32% and 34% (assessor 2) of patients after each cumulative dose when compared with combined T1- and T2-weighted pre-contrast images. Significantly more lesions (P < 0.01) were noted by both assessors after the first injection and by one assessor after each subsequent injection. For patients with just one lesion observed on unenhanced T1- and T2-weighted images, additional lesions were noted in 12%, 16% and 28% of patients by assessor 1 following each dose and in 24%, 27% and 30% of patients by assessor 2. Contemporaneously, diagnostic confidence was increased and lesion conspicuity improved over unenhanced MRI. For patients with one lesion observed after an initial dose of 0.05 mmol/kg, additional lesions were noted by assessors 1 and 2 in 9.1% and 11.8% of patients, respectively, after a cumulative dose of 0.1 mmol/kg and in a further 9.1% and 5.9% of patients, respectively, after a cumulative dose of 0.2 mmol/kg. No safety concerns were apparent.

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Section: Discussionmentioning

confidence: 98%

Magnetic resonance imaging of metastatic disease to the brain with gadobenate dimeglumine

Balériaux

Colosimo

Ruscalleda³

et al. 2002

Neuroradiology

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“…166 Meningiomas were found to have, on average, higher MTR values than other tumors, and soft tumors were found to have lower MTR values than hard tumors. 166 The application of an MT pulse to postcontrast T1-weighted images enabled a higher number of lesions to be detected in patients with brain metastases than did plain T1-weighted images, 167,168 with a sensitivity similar to that achieved with administration of a triple dose of Gd.…”

Section: Tumorsmentioning

confidence: 99%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

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“…MT images were acquired using a spin echo sequence [TR/TE = 5000/8.5 ms, with or without saturation (10 Gaussian pulses of 5 ms, interpulse delay = 300 ms, Figure 2. T 2 -weighted (TE = 75ms) longitudinal follow-up (10,12,14,18 and 21 days after inoculation) of a C6 glioma (pointed out by arrows) and the corresponding histology section at the end point. The presence of a large necrotic core does not allow a perfect slicing and explains the burst observed on the section.…”

Section: Animal Modelmentioning

confidence: 99%

High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour

et al. 2000

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Contrast-enhanced magnetisation transfer MRI in metastatic lesions of the brain

Cited by 20 publications

References 20 publications

Magnetic resonance imaging of metastatic disease to the brain with gadobenate dimeglumine

Magnetic resonance imaging of metastatic disease to the brain with gadobenate dimeglumine

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour

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