Contrast-enhanced FDG-PET/CT vs. spio-enhanced MRI vs. FDG-PET vs. CT in patients with liver metastases from colorectal cancer: a prospective study with intraoperative confirmation

Rappeport, Eli D; Loft, Annika; Berthelsen, Anne Kiil; Recke, Peter von der; Larsen, Per; Mogensen, Anne Mellon; Wettergren, André; Rasmussen, Allan; Hillingsoe, Jens; Kirkegaard, Preben; Thomsen, Carsten

doi:10.1080/02841850701294560

Cited by 122 publications

(106 citation statements)

References 35 publications

(48 reference statements)

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“…10 Rappeport et al reported that SPIONbased contrast agents, such as ferumoxides and ferucarbotrans, are specifically used for spleen and liver MR imaging because these agents are taken up by both macrophages in the spleen and Kupffer cells in the liver. 36,37 In the present study, we also observed accumulation of iron in both organs.…”

supporting

confidence: 68%

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt¹,

Saghafian²,

Kuiper³

et al. 2013

IJN

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supporting

confidence: 68%

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt¹,

Saghafian²,

Kuiper³

et al. 2013

IJN

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“…Compared to contrast-enhanced CT, MRI and especially SPIO-enhanced MRI seem to have a slightly superior sensitivity and specificity whereas PET clearly has an inferior sensitivity but superior specificity for CRLM; furthermore PET can also detect more patients with extrahepatic disease [33]. The lower costs and widespread availability however may favor the use of CT over MRI despite the radiation dose, especially if the accuracy of detection and characterization of focal liver lesions further improves with dynamic or at least multiphase CT.…”

Section: Discussionmentioning

confidence: 99%

Total-liver-volume perfusion CT using 3-D image fusion to improve detection and characterization of liver metastases

et al. 2008

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The purpose of this study was to evaluate the feasibility of a totalliver-volume perfusion CT (CTP) technique for the detection and characterization of liver metastases. Twenty patients underwent helical CT of the total liver volume before and 11 times after intravenous contrast-material injection. To decrease distortion artifacts, all phases were co-registered using 3-D image fusion before creating blood-flow maps. Lesion-based sensitivity and specificity for liver metastases of first the conventional four phases (unenhanced, arterial, portal venous, and equilibrium) and later all 12 phases including blood-flow maps were determined as compared to intraoperative ultrasound and surgical exploration. Arterial and portal venous perfusion was calculated for normalappearing and metastatic liver tissue.Total-liver-volume perfusion values were comparable to studies using single-level CTP. Compared to fourphase CT, total -liver-volume CTP increased sensitivity to 89.2 from 78.4% (P=0.046) and specificity to 82.6 from 78.3% (P=0.074). Totalliver-volume CTP is a noninvasive, quantitative, and feasible technique. Preliminary results suggest an improved detection of liver metastases for CTP compared to four-phase CT.

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“…Furthermore, the findings also suggest that when PET/CT using low-dose CT for attenuation correction is performed, several liver metastases will not be found as low-dose CT used for attenuation correction will never find such small metastases. However, larger series are needed to confirm the results of this study (1), which makes for highly recommended reading.…”

mentioning

confidence: 87%