Contrast-enhanced endoscopic ultrasonography features of a mucoepidermoid carcinoma of the pancreas

Kitagawa, Sho; Suii, Hirokazu; Miyakawa, Hiroyoshi

doi:10.4103/eus.eus_25_17

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…The reported median survival time from the diagnosis of anaplastic carcinoma of the pancreas ranges from 3.3 months ( 9 ) to 12.8 months ( 10 ), which is significantly shorter than that of common PDAC. Mucoepidermoid carcinoma is most frequently seen in the salivary glands and is uncommon in the pancreas ( 11 ). There have been a few case reports of mucoepidermoid carcinoma of the pancreas, and the survival times were 2-45 months ( 5 - 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…CT is also limited in its ability to distinguish mucoepidermoid carcinoma from other types of pancreatic carcinoma, because of its low specificity ( 3 ). EUS findings of anaplastic carcinoma of the pancreas show a hypoechoic and heterogeneous pattern ( 19 ), and the findings of mucoepidermoid carcinoma are hypoechoic pattern with slightly high internal echoes ( 11 ). In the present case, EUS revealed a hypoechoic mass with irregular margins, findings similar to those of common PDAC.…”

Section: Discussionmentioning

confidence: 99%

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Rapidly Progressing Anaplastic Carcinoma of the Pancreas with Mucoepidermoid Carcinoma: An Autopsy Case Report

Imazu

Tsuda

et al. 2021

Intern. Med.

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A 75-year-old man visited our hospital for the examination of a tumor in the pancreas. Computed tomography showed an 85×85-mm low-density tumor in the pancreas. The tumor was pathologically diagnosed as poorly differentiated carcinoma by endoscopic ultrasound-guided fine-needle aspiration. Although we started chemotherapy, the patient died 84 days after the diagnosis. An autopsy demonstrated a ruptured anaplastic carcinoma with mucoepidermoid carcinoma of the pancreas. Anaplastic carcinoma with mucoepidermoid carcinoma is a very rare histologic subtype of pancreatic carcinoma, so pathological findings are important for predicting the patient's prognosis. Physicians should be aware of this rare but fatal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rapidly Progressing Anaplastic Carcinoma of the Pancreas with Mucoepidermoid Carcinoma: An Autopsy Case Report

Imazu

Tsuda

et al. 2021

Intern. Med.

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“…English papers published from 1959 to 2020 were searched using the PubMed database with the search terms "mucoepidermoid carcinoma", "MEC", "pancreas" and "pancreatic", and only eleven cases were found. 4,5,[15][16][17][18][19] Clinicopathologic characteristics of these patients, including age, sex, treatment and prognosis, were collected for a better understanding of pancreatic MEC (Table 2). To date, the gene mutation sites in pancreatic MEC are unknown.…”

Section: Discussionmentioning

confidence: 99%

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

Chen

Zhang

Huang

et al. 2021

OTT

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Background Primary pancreatic mucoepidermoid carcinoma (MEC) is an extremely rare malignant tumor with unclear etiology and pathogenesis. There are only eleven reported cases in English papers published from 1959 to 2020. MEC generally occurs in the salivary gland, but cases in the pancreas have also been reported. Although being considered as a low-grade indolent carcinoma, pancreatic MEC always invades the surrounding lymph node and metastasizes. The prognosis of pancreatic MEC is unsatisfactory. To date, the genetic alterations, mechanistic relationships among mutated genes and signaling pathways of pancreatic MEC are unclear. Patient and Methods This paper presents a case of rare primary pancreatic MEC in a 56-year-old male patient with liver metastasis. Radical surgery of distal pancreatectomy and radiofrequency ablation (RFA) of two liver metastatic lesions is conducted. Targeted-gene sequencing and bioinformatics analysis tools, including STRING, DAVID, cBioPortal, DGidb and Human Protein Atlas database (HPA), are used to clarify the biological functions and features of mutated genes in pancreatic MEC. Results Eight gene mutations (TP53, KRAS, ATR, FLI1, FLT4, MAGI2, RBM10, and TNFAIP3) were observed, and a tumor mutation burden (TMB) of 5.6 muts/Mb was calculated in the pancreatic MEC using targeted-gene sequencing. The patient subsequently underwent adjuvant chemotherapy and died three months after surgery. Gene–gene interaction network was constructed, which showed the significant interactions among eight mutated genes. In terms of the functions and pathways of eight gene mutations based on GO and KEGG, 20 tumor-related results are presented in this paper, Furthermore, the biological functions and features of pancreatic MEC are further compared with pancreatic ductal adenocarcinoma. Conclusion Pancreatic MEC requires early and effective treatment, and lymph node metastases and multiple organ metastases were unfavorable prognostic factors. Pancreatic MEC can be compared with other pancreatic cancers that have characteristic clinical phenotype, molecular alterations, functional information and enrichment pathway.

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Contrast-enhanced endoscopic ultrasonography features of a mucoepidermoid carcinoma of the pancreas

Cited by 2 publications

References 4 publications

Rapidly Progressing Anaplastic Carcinoma of the Pancreas with Mucoepidermoid Carcinoma: An Autopsy Case Report

Rapidly Progressing Anaplastic Carcinoma of the Pancreas with Mucoepidermoid Carcinoma: An Autopsy Case Report

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

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