Contrast-enhanced digital mammography and other techniques based on image subtraction

Abstract

A method to optimize the image acquisition protocol of a MicroCT unit for preclinical studies using contrast-enhanced digital subtraction AIP Conference Proceedings 1747, 080003 (2016) Abstract. This article reviews research done by the author and collaborators in the general area of subtraction techniques applied to radiological images, in particular in contrast-enhanced digital mammography (CEDM). Main achievements have been the development and phantom validation of a general formalism to subtract images using dual-energy or temporal modalities, the proposal of a hybrid modality called dual-energy temporal, and of a matrix-based compensation for the energy dependence of the anatomical background for dual-energy subtraction. This has been validated with nonhomogenous phantom measurements and applied to clinical images using iodine-based contrast medium. Results from the clinical study have led the group to study the correlation between CEDM image parameters and angiogenic biomarkers in a murine breast cancer model. Clinical CEDM subtracted images have been subjected to textural analysis.

Contrast Enhanced Radiography with a Printed Model

“…where RV being the resulting pixel value, E1V being the pixel values for the low-energy image, E2Vthe pixel values of the high-energy image and c is a coefficient, which depends on the attenuation coefficients of the background tissue for the low-and high-x-ray energy used [8,9].…”

Contrast Agent Dual Energy Imaging: Computer Simulations In Search For Printing Materials

“…Further, the authors reported iodine concentrations required for use of CEDEM with a clinical system turned to be higher than those required for use with a synchrotron source. Brandan [4] reviewed a series of investigations in the field of DES and SETS. The author reported both theoretical studies and such that are based on phantom experiments, which proved that SETS is superior to the DES technique.…”