Contrast echocardiographic diagnosis of PTCA-induced coronary artery-left ventricle fistula

Grill, Howard P.; Chew, Paul H.; Weiss, James L.; Merillat, John C.; Hill, Gary E.; Cadden, J.F.; Brinker, Jeffrey A.

doi:10.1016/0002-8703(91)90974-m

Cited by 15 publications

(6 citation statements)

References 10 publications

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“…In the majority of previously reported cases the extravasations of contrast material with clearing into one of the ventricles was noticed on angiographic images shortly after balloon inflation [11–16], which was consistent with our observation. However in the report of Meng and Harlana[17], large false aneurysm was seen immediately after vessel dilatation, but on repeat coronary angiography performed 6 hr later, a left anterior descending coronary artery to right ventricle fistula related to false aneurysm rupture was observed.…”

Section: Discussionsupporting

confidence: 92%

“…The clinical course of this complication described by different investigators varied widely. In the three cases reported, balloon inflation that resulted in fistula formation was accompanied or followed by chest pain [11, 12], arterial hypotension [11–13], or both. In our case, the fistula was formed immediately after stent deployment but was not accompanied by chest pain or hemodynamic compromise.…”

Section: Discussionmentioning

confidence: 99%

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Fistula between right coronary artery vein graft and right atrium as an immediate complication of percutaneous coronary intervention

Hosieny

Hui

2012

Cathet Cardio Intervent

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Fistula between saphenous vein graft (SVG) and a cardiac chamber or structure is a rare complication after coronary artery bypass grafting (CABG). We report the first case of a fistula between SVG and the right atrium (RA) as an immediate complication after a percutaneous coronary intervention (PCI) in an 86-year-old female. She presented with inferior ST-elevation myocardial infarction (STEMI) and was treated with thrombolytic therapy in a peripheral hospital, which was unsuccessful. PCI to SVG to the right coronary (RCA) was complicated by a fistula to RA. Cardiac magnetic resonance (CMR) confirmed the site of the fistula and also presence of a significant arteriovenous (AV) shunt. Reversal of anticoagulation had no effect on fistula closure. Therefore, a covered stent was deployed for closure of the fistula to avoid long-term complications of the significant AV shunt. In summary, the diagnosis and appropriate management of this rare complication is challenging, but excellent result can be achieved by the use of appropriate percutaneous techniques.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Fistula between right coronary artery vein graft and right atrium as an immediate complication of percutaneous coronary intervention

Hosieny

Hui

2012

Cathet Cardio Intervent

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“…NCAM plays an important role in cell adhesion through heterophilic interactions with L1CAM. Moreover, neural cell adhesion molecule (NCAM) was found to be upregulated upon metabolic stress in cardiomyocytes 26 and reported to be associated with cardiac vascular development 27 . NCAM genetic variants have been demonstrated to be important heritable predictors of cardiovascular disease, such as hypertension 28 .…”

Section: Introductionmentioning

confidence: 99%

“…NCAM genetic variants have been demonstrated to be important heritable predictors of cardiovascular disease, such as hypertension 28 . During hypertension-induced LV remodelling, which leads to heart failure, NCAM was found to be highly expressed 27 . Notably, Nagao et al 29 showed that NCAM may be involved in LV remodelling with heart failure in a study conducted using 64 human cardiac tissue samples of patients with dilated cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

et al. 2021

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Targeting the molecular pathways underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin (Dox) could reduce the morbidity and mortality associated with these anticancer treatments. Here, we find that vascular endothelial cells (ECs) with persistent DNA damage induced by irradiation and Dox treatment exhibit a fibrotic phenotype (endothelial–mesenchymal transition, EndMT) correlating with the colocalization of L1CAM and persistent DNA damage foci. We demonstrate that treatment with the anti-L1CAM antibody Ab417 decreases L1CAM overexpression and nuclear translocation and persistent DNA damage foci. We show that in whole-heart–irradiated mice, EC-specific p53 deletion increases vascular fibrosis and the colocalization of L1CAM and DNA damage foci, while Ab417 attenuates these effects. We also demonstrate that Ab417 prevents cardiac dysfunction-related decrease in fractional shortening and prolongs survival after whole-heart irradiation or Dox treatment. We show that cardiomyopathy patient-derived cardiovascular ECs with persistent DNA damage show upregulated L1CAM and EndMT, indicating clinical applicability of Ab417. We conclude that controlling vascular DNA damage by inhibiting nuclear L1CAM translocation might effectively prevent anticancer therapy-associated cardiotoxicity.

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“…If contrast dye drains into a cardiac cavity, such as ventricle or coronary sinus, the subtype CS for cavity spilling is discriminated. Type IIICS perforation into right [28,[33][34][35] or left ventricle [36][37][38], right atrial space [39], or coronary sinus [40] are rare complications.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of a saccular pseudoaneurysm formation two weeks after perforation of the left anterior descending coronary artery during balloon angioplasty in acute myocardial infarction

Schöbel

Voelker

Haase

et al. 1999

Cathet. Cardiovasc. Intervent.

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Contrast echocardiographic diagnosis of PTCA-induced coronary artery-left ventricle fistula

Cited by 15 publications

References 10 publications

Fistula between right coronary artery vein graft and right atrium as an immediate complication of percutaneous coronary intervention

Fistula between right coronary artery vein graft and right atrium as an immediate complication of percutaneous coronary intervention

An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

Occurrence of a saccular pseudoaneurysm formation two weeks after perforation of the left anterior descending coronary artery during balloon angioplasty in acute myocardial infarction

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