Contrast-agent-enhanced ultrasound thermal ablation

Tung, Yu-Chi; Liu, Hao-Li; Wu, Chih‐Ching; Ju, Kuen-Cheng; Chen, Wen-Shiang; Lin, Win-Li

doi:10.1016/j.ultrasmedbio.2006.04.005

Cited by 81 publications

(70 citation statements)

References 12 publications

(11 reference statements)

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“…Many research efforts have been made to create nucleation sites for cavitation and reduce cavitation threshold. Both ultrasound contrast agents (UCAs) [13][14][15][16][17][18] and nanoparticles have been studied as methods to deliver cavitation nuclei into the targeted region. 19,20 The use of UCA or nanoparticles, however, requires the systematic injection of foreign particles into the blood stream, and would have major concerns regarding toxicity, efficiency, etc.…”

mentioning

confidence: 99%

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Cui

Zhang²,

Yang³

2013

Applied Physics Letters

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Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potential to enhance cavitation effect by reducing cavitation threshold in vivo. High intensity focused ultrasound (HIFU) is a truly noninvasive thermal-ablation technique. HIFU works through rapidly depositing high intensity ultrasound energy into a small region to induce cell death primarily by hyperthermia after high intensity ultrasound is absorbed by soft tissue. [1][2][3][4][5] While the application of HIFU therapy is expanding, one concern related to HIFU treatment is the prolonged treatment time for large tumors because HIFU lesion is relatively small for each HIFU shot.Cavitation has been shown to yield elevated heating rate above those produced by classical acoustic absorption in tissue and can provide an effective method to improve the efficiency of HIFU treatment.6-12 However, pre-existing nucleation sites for cavitation are not omnipresent in most tissues in vivo. Many research efforts have been made to create nucleation sites for cavitation and reduce cavitation threshold. Both ultrasound contrast agents (UCAs) [13][14][15][16][17][18] and nanoparticles have been studied as methods to deliver cavitation nuclei into the targeted region.19,20 The use of UCA or nanoparticles, however, requires the systematic injection of foreign particles into the blood stream, and would have major concerns regarding toxicity, efficiency, etc. Cavitation bubbles can also be induced in presonication areas by using low frequency, high intensity ultrasound prior to HIFU treatments. 21,22 This technique can enhance cavitation and create larger size lesions in deep tissue without the injection of any contrast agents. However, this technique requires very high acoustic pressure (generally more than 10 MPa) to be delivered into soft tissues in order to induce cavitation in the beginning. In addition, the inception of cavitation is erratic and difficult to predict when induced by ultrasound alone.Laser light has been widely used as a reliable method to induce cavitation through optical breakdown. This procedure is generally performed with high intensity light, and mostly limited to clear media or sample surfaces. 23,24 Hence the application of this technique is limited in the in vivo applications, where treatments in a certain depth in turbid media are often desired.In a previous study, 25 we reported an enhanced heating effect during photoacoustic imaging-guided HIFU therapy. The results suggested that cavitation was enhanced when a diagnostic laser light beam illuminated the sample concurrently with HIFU radiation. Two features were highlighted...

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mentioning

confidence: 99%

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Cui

Zhang²,

Yang³

2013

Applied Physics Letters

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“…The volumetric oscillation of bubbles increases ultrasonic energy dissipation in the vicinity of the bubbles through three mechanisms such as acoustic radiation, thermal, and viscous damping, which resulted in the enhanced heating effect. The effect of bubble-enhanced ultrasonic heating has been investigated experimentally [11][12][13][14][15][16][17][18][19][20][21][22][23][24] and numerically [25,26]. Although increased heat depositions were obtained using microbubbles in the previous research, distorted coagulation regions or temperature distribution were observed, such as tad-pole shaped [12,22,24] or pre-focal [13,19,[24][25][26] heating regions.…”

Section: Introductionmentioning

confidence: 99%

“…The effect of bubble-enhanced ultrasonic heating has been investigated experimentally [11][12][13][14][15][16][17][18][19][20][21][22][23][24] and numerically [25,26]. Although increased heat depositions were obtained using microbubbles in the previous research, distorted coagulation regions or temperature distribution were observed, such as tad-pole shaped [12,22,24] or pre-focal [13,19,[24][25][26] heating regions. A "trigger 2 of 20 HIFU" sequence that consists of high-intensity short pulses and following moderate-intensity long bursts has been investigated to avoid such distorted coagulation regions while enhancing the ultrasonic heating [27][28][29][30][31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

2017

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Abstract:A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named "trigger HIFU exposure" which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

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“…상에서는 고조파 신호량의 증가를 제공한다 [2] . 캐비테 이션 발생에 대한 연구 중 서로 다른 두 개의 초음파 를 교차시키면 중첩 현상에 의하여 캐비테이션 발생 량이 증가하고 [3], [4] , 열 상승 효과도 향상된다는 다양한 연구가 보고되었는데 [5], [6] , 추세이다 [7], [8] . 글리세롤 기반 초음파 조직 유사 팬텀은 IEC 60601-2-37에 명시되어 있는 초음파 연부 조직 유사 팬텀 제 작 기준규격을 이용하여 제작하였다 [9] .…”

Section: ⅰ Introductionunclassified

Heating Characteristics Evaluation of Superposed Sonication Using Glycerol Tissue Mimic Phantom

Noh¹,

Kang²,

Park³

et al. 2015

Journal of the Korean Society of Radiology

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In this study, we evaluated the heating characteristics of single sonication and superposed two low-intensity ultrasonic sonication. Compare the results, the superposed sonication was showed a superior thermal effect than single sonication. And the maximum temperature was increased as 120-150%. The starting time of temperature rising has been shortened in superposed sonication. In addition, the time up to the maximum temperature has been shortened, too. In generally, as the ultrasonic intensity is higher, the more surface damage is occurred. However, in the case of superposed sonication, the same thermal effect had be confirmed without surface damage. Through the results of the study, we thought that the superposed sonication will be able to reduce the intensity of the ultrasonic treatment. And, by using the low-intensity, the more safe and more effect therapy will be possible in therapeutic ultrasound application.

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Contrast-agent-enhanced ultrasound thermal ablation

Cited by 81 publications

References 12 publications

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

Heating Characteristics Evaluation of Superposed Sonication Using Glycerol Tissue Mimic Phantom

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