Contralateral suppression of distortion product otoacoustic emissions and the middle-ear muscle reflex in human ears

Sun, Xiao‐Ming

doi:10.1016/j.heares.2007.12.004

Cited by 43 publications

(32 citation statements)

References 37 publications

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“…A frequency shift in fine structure patterns is not as easily explained by this differential change in DPOAE component level. However, these and previous results ͑Zhang et Purcell et al, 2008;Sun, 2008aSun, , 2008bAbdala et al, 2009͒ definitively indicate that frequency shifts in fine structure patterns are at least as responsible as the release of the overlap component from cancellation for the enhancements observed at DPOAE minima due to MOC activation.…”

Section: B the Second Dimension: A Shift In Frequencysupporting

confidence: 45%

“…Most recently, an in-depth examination of efferent alteration of DPOAE fine structure has become one of the foci of this area of work ͑Zhang et Purcell et al, 2008;Sun, 2008aSun, , 2008bAbdala et al, 2009͒. We begin by highlighting the consistency of these results with previous work and then discussing the issues of the frequency shift observed in fine structure patterns and the most appropriate clinical measure of the efferent control of DPOAEs.…”

Section: Discussionmentioning

confidence: 79%

“…It has long been speculated ͑Siegel and Kim, 1982;Maison and Liberman, 2000;Kim et al, 2001;Zhang et al, 2007;Purcell et al, 2008;Sun, 2008a and more recently documented ͑Abdala et al, 2009͒ that the activation of the efferents has a differential effect on the two DPOAE components, with the component from the CF region being affected more than the component from the overlap region. However, this greater effect has been demonstrated for component levels only.…”

Section: B the Second Dimension: A Shift In Frequencymentioning

confidence: 99%

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Contralateral acoustic stimulation alters the magnitude and phase of distortion product otoacoustic emissions

Deeter

Abel

Calandruccio

et al. 2009

The Journal of the Acoustical Society of America

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Activation of medial olivocochlear efferents through contralateral acoustic stimulation ͑CAS͒ has been shown to modulate distortion product otoacoustic emission ͑DPOAE͒ level in various ways ͑enhancement, reduction, or no change͒. The goal of this study was to investigate the effect of a range of CAS levels on DPOAE fine structure. The 2f 1 -f 2 DPOAE was recorded ͑f 2 / f 1 = 1.22, L 1 = 55 dB, and L 2 =40 dB͒ from eight normal-hearing subjects, using both a frequency-sweep paradigm and a fixed frequency paradigm. Contamination due to the middle ear muscle reflex was avoided by monitoring the magnitude and phase of a probe in the test ear and by monitoring DPOAE stimulus levels throughout testing. Results show modulations in both level and frequency of DPOAE fine structure patterns. Frequency shifts observed at DPOAE level minima could explain reports of enhancement in DPOAE level due to efferent activation. CAS affected the magnitude and phase of the DPOAE component from the characteristic frequency region to a greater extent than the component from the overlap region between the stimulus tones. This differential effect explains the occasional enhancement observed in DPOAE level as well as the frequency shift in fine structure patterns.

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Section: B the Second Dimension: A Shift In Frequencysupporting

confidence: 45%

Section: Discussionmentioning

confidence: 79%

Section: B the Second Dimension: A Shift In Frequencymentioning

confidence: 99%

See 1 more Smart Citation

Contralateral acoustic stimulation alters the magnitude and phase of distortion product otoacoustic emissions

Deeter

Abel

Calandruccio

et al. 2009

The Journal of the Acoustical Society of America

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“…Such levels have been shown not to induce a MEM contribution to contralateral suppression (Giraud et al, 1995;Sun, 2008). The MEM reflex threshold was measured on the first training day using standard clinical procedures on a GSI 33 tympanometer.…”

Section: Mocb Measurementsmentioning

confidence: 99%

Neural Correlates of Perceptual Learning in the Auditory Brainstem: Efferent Activity Predicts and Reflects Improvement at a Speech-in-Noise Discrimination Task

Boer¹,

Thornton²

2008

J. Neurosci.

182

170

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An extensive corticofugal system extends from the auditory cortex toward subcortical nuclei along the auditory pathway. Corticofugal influences reach even into the inner ear via the efferents of the olivocochlear bundle, the medial branch of which modulates preneural sound amplification gain. This corticofugal system is thought to contribute to neuroplasticity underlying auditory perceptual learning. In the present study, we investigated the involvement of the medial olivocochlear bundle (MOCB) in perceptual learning as a result of auditory training. MOCB activity was monitored in normal-hearing adult listeners during a 5 d training regimen on a consonant-vowel phoneme-in-noise discrimination task. The results show significant group learning, with great inter-individual variability in initial performance and improvement. As observed in previous auditory training studies, poor initial performers tended to show greater learning. Strikingly, MOCB activity measured on the first training day strongly predicted the subsequent amount of improvement, such that weaker initial MOCB activity was associated with greater improvement. Moreover, in listeners that improved significantly, an increase in MOCB activity was observed after training. Thus, as discrimination thresholds of listeners converged over the course of training, differences in MOCB activity between listeners decreased. Additional analysis showed that MOCB activity did not explain variation in performance between listeners on any training day but rather reflected an individual listener's performance relative to their personal optimal range. The findings suggest an MOCB-mediated listening strategy that facilitates speech-in-noise perception. The operation of this strategy is flexible and susceptible to training, presumably because of task-related adaptation of descending control from the cortex.

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“…This suggests that the level of contralateral noise selected in the study was below the AR thresholds of all of the subjects evaluated, and implicates the involvement of the MOC efferent neurons in the observed suppression of DPOAEs. While AR activity below the measured AR thresholds cannot be ruled out, Sun [34] reported that the suppression of DPOAEs for levels of contralateral noise below the AR threshold is most likely is mediated by the MOC reflex pathway. The level of the 2f 1 − f 2 DPOAEs is known to diminish rapidly within 100 msec of the onset of presentation of the primary tones, presumably due to ipsilateral activation of the crossed MOC reflex [35].…”

Section: Effects Of Contralateral Noise On Dpoae I/o Functionsmentioning

confidence: 93%

The Role of Efferent Reduction of Cochlear Compression in the Detection of Tones in Noise

Bhagat¹,

Yellamsetty²

2017

OJA

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Stimulation of medial olivocochlear (MOC) efferent neurons reduces basilar membrane (BM) sensitivity and increases the slope of BM input-output (I/O) functions in animal models. Decreased compression of I/O functions associated with activation of MOC efferent neurons may assist in extending the neural response to the tone above that of noise, leading to an improvement in masked thresholds. To evaluate this hypothesis, the distortion-product otoacoustic emission (DPOAE) I/O function, a proxy measure of BM compression, was examined in conditions with presentation of contralateral noise.

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Contralateral suppression of distortion product otoacoustic emissions and the middle-ear muscle reflex in human ears

Cited by 43 publications

References 37 publications

Contralateral acoustic stimulation alters the magnitude and phase of distortion product otoacoustic emissions

Contralateral acoustic stimulation alters the magnitude and phase of distortion product otoacoustic emissions

Neural Correlates of Perceptual Learning in the Auditory Brainstem: Efferent Activity Predicts and Reflects Improvement at a Speech-in-Noise Discrimination Task

The Role of Efferent Reduction of Cochlear Compression in the Detection of Tones in Noise

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