Contralateral Repeated Bout Effect of Eccentric Exercise of the Elbow Flexors

Chen, Trevor Chung Ching; Chen, Hsin‐Lian; Lin, Ming-Ju; Yu, Hui I.; Nosaka, Kazunori

doi:10.1249/mss.0000000000000991

Cited by 49 publications

(105 citation statements)

References 30 publications

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“…Furthermore, systemic or contralateral intramuscular injections of recombinant IL-10 inhibit acidic saline-induced muscle hyperalgesia in mice [27]. This fits well with the fact that RBE is also observed when first and second bouts of eccentric exercise are applied to different limbs [11,23,37], suggesting a role of a diffusible antinociceptive mediator, such as IL-10.…”

Section: Discussionmentioning

confidence: 58%

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat

Álvarez

Bogen

Green

et al. 2017

PAIN

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Delayed-onset muscle soreness is typically observed after strenuous or unaccustomed eccentric exercise. Soon after recovery, blunted muscle soreness is observed on repeated eccentric exercise, a phenomenon known as repeated bout effect (RBE). Although regular physical activity decreases muscle hyperalgesia, likely because of increased production of the anti-inflammatory cytokine interleukin-10 (IL-10) in the skeletal muscle, whether IL-10 also contributes to the antinociceptive effect of RBE is unknown. Furthermore, whether IL-10 attenuates muscle hyperalgesia by acting on muscle nociceptors remains to be established. Here, we explored the hypothesis that blunted muscle nociception observed in RBE depends on a local effect of IL-10, acting on IL-10 receptor 1 (IL-10R1) expressed by muscle nociceptors. Results show that after a second bout of eccentric exercise, rats exhibited decreased muscle hyperalgesia, indicative of RBE, and increased expression of IL-10 in the exercised gastrocnemius muscle. Although knockdown of IL-10R1 protein in nociceptors innervating the gastrocnemius muscle by intrathecal antisense oligodeoxynucleotide did not change nociceptive threshold in naive rats, it unveiled latent muscle hyperalgesia in rats submitted to eccentric exercise 12 days ago. Furthermore, antisense also prevented the reduction of muscle hyperalgesia observed after a second bout of eccentric exercise. These data indicate that recovery of nociceptive threshold after eccentric exercise and RBE-induced analgesia depend on a local effect of IL-10, acting on its canonical receptor in muscle nociceptors.

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Section: Discussionmentioning

confidence: 58%

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat

Álvarez

Bogen

Green

et al. 2017

PAIN

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“…As no significant changes in EE MVC‐CON torque were evident after 30MVEC, it is most likely that muscle damage was induced to the EF only. Several studies reported that the first maximal eccentric exercise bout of one muscle group conferred protective effect on the subsequent eccentric exercise bout of the homologous muscle of the opposite limb, which is known as the CL‐RBE. For example, Chen et al showed that changes in indirect muscle damage markers after 30MVEC of the EF were smaller when the contralateral arm performed the second bout at 1, 7, or 28 days later, but the CL‐RBE was not observed when the second bout was performed in the same day (0.5, 6, or 12 hours between bouts) or 56 days later.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported that the first maximal eccentric exercise bout of one muscle group conferred protective effect on the subsequent eccentric exercise bout of the homologous muscle of the opposite limb, which is known as the CL‐RBE. For example, Chen et al showed that changes in indirect muscle damage markers after 30MVEC of the EF were smaller when the contralateral arm performed the second bout at 1, 7, or 28 days later, but the CL‐RBE was not observed when the second bout was performed in the same day (0.5, 6, or 12 hours between bouts) or 56 days later. The extent of protective effect on EF MVC‐CON torque (15%) and ROM (31%) for the 1d group in the contralateral condition in the present study was smaller than that of the previous study in which 30MVEC were repeated by the contralateral arm 1 day later (52%, 44%).…”

Section: Discussionmentioning

confidence: 99%

“…For example, Chen et al showed that changes in indirect muscle damage markers after 30MVEC of the EF were smaller when the contralateral arm performed the second bout at 1, 7, or 28 days later, but the CL‐RBE was not observed when the second bout was performed in the same day (0.5, 6, or 12 hours between bouts) or 56 days later. The extent of protective effect on EF MVC‐CON torque (15%) and ROM (31%) for the 1d group in the contralateral condition in the present study was smaller than that of the previous study in which 30MVEC were repeated by the contralateral arm 1 day later (52%, 44%). Although the extent of the protective effect on the contralateral arm conferred by 2MVIC is smaller than that by 30MVEC, the present study found that 2MVIC still produced potent protection against muscle damage after a subsequent bout of MVEC performed by the opposite arm.…”

Section: Discussionmentioning

confidence: 99%

“…This is referred to as the contralateral repeated bout effect (CL‐RBE), which is evidenced by a faster recovery of muscle function, smaller increases in muscle proteins such as creatine kinase (CK) activity in the blood, and less development of delayed onset muscle soreness (DOMS) . Chen et al reported that the magnitude of the CL‐RBE was smaller than that of the ipsilateral repeated bout effect (IL‐RBE), and the CL‐RBE lasted for 4 weeks for the elbow flexors, but was not observed when the second bout was performed in the same day …”

Section: Introductionmentioning

confidence: 99%

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Muscle damage protective effect by two maximal isometric contractions on maximal eccentric exercise of the elbow flexors of the contralateral arm

Chen

Lin

Chen

et al. 2018

Scandinavian Med Sci Sports

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Muscle damage after 30 maximal eccentric contractions of the elbow flexors (30MVEC) is reduced when the same exercise is performed by the opposite arm, and when two maximal voluntary isometric contractions at a long muscle length (2MVIC) are performed prior to 30MVEC by the same arm. This study investigated the hypothesis that 2MVIC would attenuate muscle damage after 30MVEC performed by the opposite arm. Untrained young (20-25 years) men were placed into 1 of 4 experimental groups that performed 2MVIC at 1 (1d), 2 (2d), 4 (4d), or 7 days (7d) before 30MVEC by the opposite arm, or one control group that performed 30MVEC only (n = 13/group). Changes in indirect muscle damage markers after 30MVEC were compared among the groups by mixed-design two-way ANOVA. Maximal voluntary concentric contraction torque, range of motion, plasma creatine kinase activity, and muscle soreness did not change significantly after 2MVIC. Changes in these variables after 30MVEC were smaller (P < .05) for 1d (eg, peak soreness: 45 ± 21 mm) and 2d groups (46 ± 20 mm) than control group (66 ± 18 mm), without significant differences between 1d and 2d groups. No significant differences in the changes were found among 4d, 7d, and control groups, except for soreness showing smaller (P < .05) increases for 4d group (54 ± 19 mm) than 7d (62 ± 17 mm) and control groups. These results supported the hypothesis and showed that muscle damage induced by 30MVEC was reduced by 2MVIC performed 1-2 days prior to 30MVIC by the contralateral arm.

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Recovery of pectoralis major and triceps brachii after bench press exercise

et al. 2017

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The identification of the characteristics of each movement and its adjustment to the training goals are tasks that demand the interaction of many knowledge areas. These tasks are essential to the success in sports activities and training programs designed with athletic, aesthetic or healthy purposes. The objective of the present study was to compare the electromyographic (EMG) activity of the pectoralis major (PM), anterior deltoids (DA) and triceps brachii (TB) muscles during the barbell bench press (SP) and the peck deck (PD) exercises. EMG activity of TB, PM and DA were assessed during 10 maximum repetitions performed in SP and PD in 13 trained men. The results did not show any differences between exercises for PM and DA activity; however, TB activity was higher for SP than PD exercise. During SP, the PM muscle activity was higher than TB. There were no differences between PM and DA, or between DA and TB. During the PD exercise, the PM and DA muscle activities were higher than TB. There were no differences between PM and DA. It was concluded that the prime mov-ers of both exercise are DA and PM, and there are no differences between them. Therefore, both PD and SP could be performed with the purpose to stimulate DA and PM muscles, depending on the availability of the equipments and/or the specificity of the motor tasks.

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Contralateral Repeated Bout Effect of Eccentric Exercise of the Elbow Flexors

Abstract: These results suggest that the CL-RBE lasts shorter than the ipsilateral RBE (>8 wk) and requires a day to be conferred.

Cited by 49 publications

References 30 publications

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat

Muscle damage protective effect by two maximal isometric contractions on maximal eccentric exercise of the elbow flexors of the contralateral arm

Recovery of pectoralis major and triceps brachii after bench press exercise

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