Contralateral mechanical hyperalgesia and altered pain modulation in men who have unilateral insertional Achilles tendinopathy: A cross-sectional study

Vallance, Patrick; Crowley, Liam; Vicenzino, Bill; Malliaras, Peter

doi:10.1016/j.msksp.2021.102353

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…This meta-analysis included 34 studies out of 2868 retrieved records ( Figure 1 ) [ 11 , 12 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. These 34 studies addressed 9 different tendinopathies: 11 were on lateral epicondylalgia, 5 were on Achilles tendinopathy, 4 were on shoulder impingement syndrome, 3 were on great trochanter pain syndrome, 3 were on patellar tendinopathy, 2 were on rotator cuff tears, 2 were on plantar heel pain, 2 were on all lower limb tendinopathies (greater trochanteric pain syndrome, quadriceps tendinopathy, patellar tendinopathy, Achilles tendinopathy, and plantar heel pain), 1 was on ilio-tibial band syndrome, and 1 included both patients with patellar and Achilles tendinopathy.…”

Section: Resultsmentioning

confidence: 99%

“…−2.55; −1.32; p < 0.001). No significant difference in contralateral PPTs was documented in the sub-analyses on shoulder impingement syndrome and Achilles tendinopathy, with all studies on these tendinopathies reporting no differences between groups except for the study of Vallance et al on Achilles tendinopathy [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…The definition of cases was considered appropriate in all the included studies since it was based on validated diagnostic criteria and excluded subjects with diseases that may influence results (i.e., neuropathies, other musculoskeletal diseases). The representativeness of the included subjects was rated as inappropriate in six studies: Fernandez del la Peñas et al, Hamstra-Wright et al, Jespersen et al, and Plinsinga et al included only, or almost only, females [ 25 , 29 , 30 , 38 ], whereas Van Wilgen et al [ 48 ] and Vallance et al [ 44 ] included only males. The selection and the definition of controls were rated appropriate in all studies including a control group.…”

Section: Resultsmentioning

confidence: 99%

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Tendinopathies and Pain Sensitisation: A Meta-Analysis with Meta-Regression

Previtali¹,

Mameli²,

Zaffagnini

et al. 2022

Biomedicines

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The presence of pain sensitisation has been documented and reported as being a possible cause of treatment failure and pain chronicity in several musculoskeletal conditions, such as tendinopathies. The aim of the present study is to analyse existing evidence on pain sensitisation in tendinopathies comparing the local and distant pain thresholds of healthy and affected subjects with distinct analysis for different tendinopathies. PubMed, Cochrane Central Register, Scopus, and Web Of Science were systematically searched after registration on PROSPERO (CRD42020164124). Level I to level IV studies evaluating the presence of pain sensitisation in patients with symptomatic tendinopathies, documented through a validated method, were included. A meta-analysis was performed to compare local, contralateral, and distant pain thresholds between patients and healthy controls with sub-analyses for different tendinopathies. Meta-regressions were conducted to evaluate the influence of age, activity level, and duration of symptoms on results. Thirty-four studies out of 2868 were included. The overall meta-analysis of local pressure pain thresholds (PPT) documented an increased sensitivity in affected subjects (p < 0.001). The analyses on contralateral PPTs (p < 0.001) and distant PPTs (p = 0.009) documented increased sensitivity in the affected group. The results of the sub-analyses on different tendinopathies were conflicting, except for those on lateral epicondylalgia. Patients’ activity level (p = 0.02) and age (p = 0.05) significantly influenced local PPT results. Tendinopathies are characterized by pain sensitisation, but, while features of both central and peripheral sensitisation can be constantly detected in lateral epicondylalgia, results on other tendinopathies were more conflicting. Patients’ characteristics are possible confounders that should be taken into account when addressing pain sensitisation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Tendinopathies and Pain Sensitisation: A Meta-Analysis with Meta-Regression

Previtali¹,

Mameli²,

Zaffagnini

et al. 2022

Biomedicines

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“…Psychological factors were evaluated in 4% (11/307) of all studies (Table 2; Fig. 2) [4,80,87,108,171,173,179,280,290,309]. The Tampa Scale of Kinesiophobia was the most…”

Section: Psychological Factorsmentioning

confidence: 99%

“…'Ankle range of motion' was reported in 4% (13/307) of the studies [17, 45, 48, 63-66, 85, 203, 242, 259, 296] and one study [259] reported first metatarsophalangeal joint range of motion. 'Pain and or tenderness with palpation' was reported in 4% (11/307) of the studies [18,37,45,48,53,77,98,113,207,234,279], and 'Sensory modality specific pain' was reported in 4% (14/307) of the studies [13,42,49,60,65,90,94,105,108,177,215,218,238,309].…”

Section: Achilles Tendinopathy Specific Domainsmentioning

confidence: 99%

ICON 2020—International Scientific Tendinopathy Symposium Consensus: A Systematic Review of Outcome Measures Reported in Clinical Trials of Achilles Tendinopathy

et al. 2021

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Background Nine core domains for tendinopathy have been identified. For Achilles tendinopathy there is large variation in outcome measures used, and how these fit into the core domains has not been investigated. Objective To identify all available outcome measures outcome measures used to assess the clinical phenotype of Achilles tendinopathy in prospective studies and to map the outcomes measures into predefined health-related core domains. Design Systematic review. Data Sources Embase, MEDLINE (Ovid), Web of Science, CINAHL, The Cochrane Library, SPORTDiscus and Google Scholar. Eligibility Criteria for Selecting Studies Clinical diagnosis of Achilles tendinopathy, sample size ≥ ten participants, age ≥ 16 years, and the study design was a randomized or non-randomized clinical trial, observational cohort, single-arm intervention, or case series. Results 9376 studies were initially screened and 307 studies were finally included, totaling 13,248 participants. There were 233 (177 core domain) different outcome measures identified across all domains. For each core domain outcome measures were identified, with a range between 8 and 35 unique outcome measures utilized for each domain. The proportion of studies that included outcomes for predefined core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. Conclusion 233 unique outcome measures for Achilles tendinopathy were identified. Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. Prospero Registration CRD42020156763.

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