Contralateral Breast Screening with Preoperative MRI: Long-Term                     Outcomes for Newly Diagnosed Breast Cancer

Freitas, Vivianne; Li, Xuan; Amitai, Yoav; Au, Frederick; Kulkarni, Supriya; Ghai, Sandeep; Mulligan, Anna Marie; Bromley, Miluska; Siepmann, Timo

doi:10.1148/radiol.212361

Cited by 18 publications

(11 citation statements)

References 64 publications

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“…In particular, two of the four patients with a high proliferation index (ki67) (20% and 60%) and lymph node negativity have benefited predictably from the earlier discovery by breast MRI [ 33 ]. In the literature, MRI screening of the contralateral breast in women with newly diagnosed breast cancer could improve overall survival with a hazard ratio of 2.51 [ 34 ]. One of the discussed limitations of breast MRI is overdiagnosis and therapy.…”

Section: Discussionmentioning

confidence: 99%

Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

et al. 2023

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Background: In the German Mammography Screening Program, 62% of ductal carcinoma in situ (DCIS) and 38% of invasive breast cancers are associated with microcalcifications (MCs). Vacuum-assisted stereotactic breast biopsies are necessary to distinguish precancerous lesions from benign calcifications because mammographic discrimination is not possible. The aim of this study was to investigate if breast magnetic resonance imaging (MRM) could assist the evaluation of MCs and thus help reduce biopsy rates. Methods: In this IRB-approved study, 58 women (mean age 58 +/− 24 years) with 59 suspicious MC clusters in the MG were eligible for this prospective single-center trial. Additional breast magnetic resonance imaging (MRI) was conducted before biopsy. Results: The breast MRI showed a sensitivity of 86%, a specificity of 84%, a positive predictive value (PPV) of 75% and a negative predictive value (NPV) of 91% for the differentiation between benign and malignant in these 59 MCs found with MG. Breast MRI in addition to MG could increase the PPV from 36% to 75% compared to MG alone. The MRI examination led to nine additional suspicious classified lesions in the study cohort. A total of 55% (5/9) of them turned out to be malignant. A total of 32 of 59 (54 %) women with suspicious MCs and benign histology were classified as non-suspicious by MRI. Conclusion: An additionally performed breast MRI could have increased the diagnostic reliability in the assessment of MCs. Further, in our small cohort, a considerable number of malignant lesions without mammographically visible MCs were revealed.

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Section: Discussionmentioning

confidence: 99%

Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

et al. 2023

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“…Preoperative MRI examination leads to an increased probability of mastectomy while reducing the recurrence rate and increasing the long-term survival rate in the meantime. However, the clinical effect of preoperative MRI on the recurrence rate and long-term survival rate remains contradictory, with some reporting a favorable effect whereas others did not note this association, which might be related to the characteristics of the patients [8,[40][41][42][43]. However, several latest clinical studies indicated a beneficiary role of constantly innovative qualitative and quantitative analysis of MRI.…”

Section: Discussionmentioning

confidence: 99%

Impact of Preoperative Magnetic Resonance Imaging on Surgical Outcomes in Women with Invasive Breast Cancer: A Systematic Review and Meta-Analysis

Zhang

Qian

et al. 2022

International Journal of Clinical Practice

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Background. Currently, whether magnetic resonance imaging (MRI) should be routinely applied to patients with breast cancer before surgery remains controversial. A pooled analysis of the association between preoperative MRI and surgical outcomes in female patients with newly diagnosed invasive breast cancer was conducted to provide evidence-based medicine for clinical practice. Methods. Three independent researchers searched the following databases: PubMed, Medline, Embase, Ovid, Cochrane Library, and Web of Science from inception to April 2022. Literature was included and excluded according to Cochrane’s principles. The basic information from eligible documents was extracted. Systematic evaluation and meta-analysis were performed, and the odds ratio (OR) was analyzed by the random-effect model. The quality of the literature was assessed using the modified Jadad scale and the Newcastle-Ottawa (NOS) mean scale. Results. A total of 19 studies were included, including 4 randomized controlled trials and 15 observational comparative studies. Among them, most studies were not limited to a specific pathological type, with the exception of 3 that were limited to invasive lobular carcinoma. The results showed that preoperative MRI examination would significantly reduce the reoperation rate (OR = 0.77, P = 0.02 ) and increase the mastectomy rate (OR = 1.36, P = 0.001 ). In comparison, preoperative MRI did not significantly affect the rate of secondary mastectomy (OR = 0.77, P = 0.02 ), the rate of positive margin (OR = 1.08, P = 0.66 ), the rate of mastectomy (OR = 1.00, P < 0.05 ), and reoperations (OR = 0.65, P = 0.19 ) in the subgroup analysis of patients with invasive lobular carcinoma. Conclusion. Available evidence suggests that preoperative MRI examination increases the rate of mastectomy and reduces the rate of reoperations. The results indicate that preoperative MRI examination has the potential to benefit patients with breast cancer, but more high-quality studies are needed for confirmation.

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“…Currently, dynamic-enhanced MRI is widely used in the diagnosis of breast cancer to develop individualized treatment plans ( 9 - 11 ). We found that the correlations between the ADC and peak time, and postoperative recurrence or metastasis and the clinical pathological features of breast cancer patients were examined, and it was found that the decreased ADC and peak time were risk factors for postoperative recurrence or metastasis in breast cancer patients and were related to the patients’ clinical pathological features.…”

Section: Discussionmentioning

confidence: 99%

Correlations between dynamic-enhanced magnetic resonance imaging quantitative parameters and postoperative recurrence or metastasis and clinicopathological features in breast cancer patients—a retrospective cohort study

Chen¹,

Gao²,

Wu³

et al. 2022

Gland Surg

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Background: Few related studies focused on the correlations between the quantitative parameters of dynamic-enhanced magnetic resonance imaging (MRI) and the clinical pathological characteristics of patients with invasive breast cancer have been conducted to date. This study sought to explore the value of quantitative parameters of dynamic-enhanced MRI in predicting postoperative recurrence or metastasis in breast cancer patients and their correlations with clinical pathological features, so as to provide clinicians with understanding of MRI in breast cancer. Methods: From January 2016 to Jun 2017, 214 invasive breast cancer patients admitted to Affiliated Kunshan Hospital of Jiangsu University were retrospectively enrolled in this study. Dynamic-enhanced MRI was performed to analyze the relationship between quantitative parameters of dynamic-enhanced MRI and recurrence or metastasis, and analyze their correlations with clinical pathological features in patients with invasive breast cancer. Results: The apparent diffusion coefficient and peak time had certain diagnostic value for postoperative recurrence or metastasis in breast cancer patients, and the areas under the curve were 0.821 [95% confidence interval (

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Contralateral Breast Screening with Preoperative MRI: Long-Term Outcomes for Newly Diagnosed Breast Cancer

Cited by 18 publications

References 64 publications

Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

Impact of Preoperative Magnetic Resonance Imaging on Surgical Outcomes in Women with Invasive Breast Cancer: A Systematic Review and Meta-Analysis

Correlations between dynamic-enhanced magnetic resonance imaging quantitative parameters and postoperative recurrence or metastasis and clinicopathological features in breast cancer patients—a retrospective cohort study

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