Contralateral axillary silicone lymphadenopathy after modified radical mastectomy and reconstruction

Dorogi, Bence; Gulyás, Gusztáv; Kunos, Csaba; Udvarhelyi, Nóra; Mátrai, Zoltán

doi:10.1007/s00238-014-0970-4

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…The actual incidence and prevalence are unknown with less than 180 cases noted in the 36 literature. To the best of our knowledge, there have been only 5 case reports concerning silicone 10,11,36,37 migration to the contralateral lymph nodes. Factors that lead to aberrant lymphatic flow include prior breast or axillary surgery or irradiation, bulky tumor in breast or heavy burden disease in the 38,39 ipsilateral lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Contralateral Axillary Lymph Node Enlargement in a Woman with Silent Silicone Breast Implant Rupture 30 Years After Breast Cancer Diagnosis: A Lesson to Be Learnt

et al. 2021

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Background: Silicone lymphadenopathy is a recognized complication of silicone implant rupture. It occurs when silicone droplets migrate from breast implants to lymph nodes, resulting in the formation of granulomas (known as siliconoma) and lymph node enlargement. The ipsilateral axillary lymph nodes are most commonly involved but it can also affect contralateral axillary, supraclavicular, internal mammary and mediastinal lymph nodes.Case presentation: A 60-year-old woman with a history of left breast cancer who had undergone modified radical mastectomy (MRM) followed by left breast reconstruction with implant (30 years ago) presented with right axillary lymph nodes enlargement. An excisional biopsy of the two larger lymph nodes was performed to rule out malignancy. Pathologic examination showed features of silicone lymphadenopathy. Further examination with Ultrasound and MRI confirmed breast implant rupture. Conclusion: Silicone lymphadenopathy following breast augmentation and reconstruction primarily affects the ipsilateral axillary nodes. Contralateral lymph node involvement is rare and may occur several years after breast cancer diagnosis and can be the first sign of breast implant rupture. Although, the need to exclude malignancy in such cases is of outmost importance, silicone lymphadenopathy should also be considered in the differential diagnosis.

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