2012
DOI: 10.1371/journal.pone.0039869
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Contraction Mechanisms in Composite Active Actin Networks

Abstract: Simplified in vitro systems are ideally suited for studying the principle mechanisms of the contraction of cytoskeletal actin systems. To shed light on the dependence of the contraction mechanism on the nature of the crosslinking proteins, we study reconstituted in vitro active actin networks on different length scales ranging from the molecular organization to the macroscopic contraction. Distinct contraction mechanisms are observed in polar and apolar crosslinked active gels whereas composite active gels cro… Show more

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Cited by 50 publications
(65 citation statements)
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“…2 i and ii and Fig. 4, right bar), consistent with previous observations in bulk networks (22)(23)(24)(25)33). The striking finding is that actin-membrane anchoring governs the outcome of cortex contraction.…”
Section: Cortex Connectivity and Membrane Attachment Govern Contractionsupporting
confidence: 90%
See 1 more Smart Citation
“…2 i and ii and Fig. 4, right bar), consistent with previous observations in bulk networks (22)(23)(24)(25)33). The striking finding is that actin-membrane anchoring governs the outcome of cortex contraction.…”
Section: Cortex Connectivity and Membrane Attachment Govern Contractionsupporting
confidence: 90%
“…We find that crushing is slower than peeling because osmotic pressure works against it. In cells, where the geometry is inside-out, cortical tension is also opposed by osmotic pressure (33). Although cells likely have additional machineries to avoid failure, actomyosin contractility can under some conditions lead to tissue tear-off at the scale of a cell layer in developing fly embryos (47).…”
Section: Force Analysis and Estimates Of Characteristic Times And Crimentioning
confidence: 99%
“…116,155,220,255,292,327,339). This was initially reported for actin filament bundles stabilized by fascin during an in vitro filament gliding assay (133).…”
Section: Myosin-induced Disassemblymentioning
confidence: 77%
“…The velocity of contraction depends on filament architecture: contraction is faster for antiparallel filaments compared with branched networks. The orientation of the actin filaments in the contracting network is thus a major determinant for controlling the rate of contraction (155,255). Moreover, the dynamics of actin polymerization and depolymerization have to be taken into account in addition to myosin activity for explaining phenomena such as actin ring contraction during cytokinesis (354).…”
mentioning
confidence: 99%
“…Active media often exhibit superdiffusion with mean-squared displacements (MSD) r 2 that vary superlinearly with time, r 2 ∝ t a with 1 < a 2, as observed in intracellular transport [47][48][49], in vitro experiments [30,45,50], and models of self-propelled particles [34][35][36]. Conversely, 0 < a < 1 is referred to as subdiffusion.…”
Section: A Dynamics Of Weakly Bound Statesmentioning
confidence: 99%