Contraction behaviour reduces embryo competence in high-quality euploid blastocysts

Gonzalez, Xavier Viñals; Odia, Rabi; Cawood, Suzanne; Gaunt, Matthew; Saab, Wael; Seshadri, Srividya; Serhal, Paul

doi:10.1007/s10815-018-1246-x

Cited by 17 publications

(23 citation statements)

References 28 publications

(36 reference statements)

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“…Moreover, in agreement with our study, a reduction in the pregnancy rate was reported if blastocysts that displayed a collapse episode were transferred, compared to the non-collapse group (47.6% versus 78.5%, respectively). Although this is the first study to report such data, it might be clear that spontaneously blastocyst collapse, despite being a physiological feature during blastulation, is conditioned by the ploidy status of the embryo (Viñals Gonzalez et al, 2018). In conclusion, the analysis of spontaneous blastocyst collapse could be used as tool to improve embryo selection, especially when there are several blastocysts available for transfer.…”

Section: Discussionmentioning

confidence: 85%

“…Although in the present study we did not perform any pre-implantation genetic screening, the chromosomal abnormalities could perhaps clarify the difference in clinical outcomes between the two groups (collapse and not collapse). A recent study published by Viñals Gonzalez et al (2018) investigates the correlation between blastocyst collapse patterns and genetic complements in human embryos. Eight hundred ninety-six good quality blastocysts were analyzed.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study

Sciorio

Thong

Pickering

2019

JBRA Assisted Reproduction

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Objective: In this study we investigate the correlation between spontaneous blastocyst collapse and pregnancy outcome. Methods: This is a retrospective study performed at Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, UK. Embryos were cultured individually in 6.0% CO 2 , 5.0% O 2 , 89.0% N 2 , using single step medium (GTL™ Vitrolife, Göteborg, Sweden) and selected for transfer using standard morphological criteria. Using the EmbryoScope™ time-lapse monitoring (TLM), blastocysts collapse was analyzed by measuring the maximum volume reduction and defined as having collapsed if there was >50% volume reduction. Couples undergoing IVF/ICSI treatment and having an elective single embryo transfer (eSET) at blastocyst stage were included in this study. After the embryo transfer, retrospectively, each blastocyst was allocated to one of two groups (collapsed or not collapsed). 62 blastocysts collapsed once or more during development (17.4%), the remaining 294 showed no collapse (82.6%). Results: A significantly higher implantation rate (IR) of 61.2% and ongoing pregnancy rate (OPR) of 53.7% was observed when blastocysts which had not collapsed were replaced compared to cycles in which collapsed blastocysts were replaced (IR rate 22.6% and OPR 17.7%). Conclusion: This study demonstrated that human blastocysts which collapse spontaneously during in vitro development are less likely to implant and generate a pregnancy compared with embryos which do not. Although this is a retrospective study, the results establish the utility of collapse episodes as new marker of embryo selection following eSET at blastocyst stage.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study

Sciorio

Thong

Pickering

2019

JBRA Assisted Reproduction

View full text Add to dashboard Cite

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“…However, still the most widely used selection protocol is a subjective, single point morphological assessment of the embryo before transfer. More recently, the introduction of time-lapse imaging has been importantly instructive; objectively demonstrating a high incidence of morphological dysmorphism during cleavage, concomitant with reduced implantation and live births, providing sophisticated morphokinetic computations as a prognosticator for embryo viability (Campbell and Fishel, 2015;Lagalla et al, 2016;Pribenszky et al, 2017;Reignier et al, 2018;Viñals Gonzalez et al, 2018;Zhan et al, 2016), and introducing machine learning to evolve independent selective algorithms for automated programming (Kohsravi et al, 2019;Tran et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Evolution of embryo selection for IVF from subjective morphology assessment to objective time-lapse algorithms improves chance of live birth

Fishel

Campbell²,

Foad

et al. 2020

Reproductive BioMedicine Online

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“…Additionally, the presence of contractions may compromise the implantation rates. [ 15 ] Taken altogether, maternal age and some morphological parameters (expansion, time of blastocyst formation, and trophectoderm grade) were associated with euploidy, whereas other parameters, such as embryo sex and biopsy day, were not related to aneuploidy. There was a positive correlation between the speed of D4 embryo development and the time of blastocyst formation.…”

Section: Discussionmentioning

confidence: 99%

Associations between a new day 4 embryo grading system and implantation rates in frozen embryo transfer (FET) cycles

Jing

et al. 2020

Medicine

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The purpose of this study is to present a new day 4 (D4) embryo grading system for the assessment of embryos in frozen-thawed embryo transfer (FET) cycles. A new grading system (grades A–E) was modified from the 2011 ESHRE Istanbul Consensus for D4 embryos in FET cycles. In total, we retrospectively analyzed 5640 embryos with known implantation data after D4 transfer in FET cycles by using this proposed grading model. The transferred embryos exhibited a similar declining trend in implantation rates from the top grade A to the lowest grade E. The implantation rates of grade B and E embryos in the in vitro fertilization group were significantly higher than that in the intracytoplasmic sperm injection group (grade B: 41.82%, 35.23%, χ 2 = 5.85, P < .05 and grade E: 18.53%, 14.81, χ 2 = 76.86, P < .01, respectively). The receiver operating characteristic analysis showed that our proposed model predicted the implantation outcomes of all embryos (area under the ROC curve = 0.65; 95% CI, 0.63–0.66; P < .01). This study demonstrated that the new grading system provided by us turned out to be a useful tool in assisting embryo selection via embryo morphological changes, and D4 embryo transfer provided a simple and applicable method for a daily routine in FET cycles.

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Contraction behaviour reduces embryo competence in high-quality euploid blastocysts

Cited by 17 publications

References 28 publications

Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study

Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study

Evolution of embryo selection for IVF from subjective morphology assessment to objective time-lapse algorithms improves chance of live birth

Associations between a new day 4 embryo grading system and implantation rates in frozen embryo transfer (FET) cycles

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