Contraction and Relaxation of Collagen Fibres

Banga, I; J, Balo; Szabó, Dániel

doi:10.1038/174788a0

Cited by 31 publications

(7 citation statements)

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“…Dieses Was ser scheint auf zweifache Art zu wirken: erstens durch Ausbildung locke rer Bindungen von H20 in Kettenform entlang der helikalen Struktur und zweitens durch Induktion von hydrophoben intramolekularen Bindungen [von H ippel und Wong, 1964;T raub und P iez, 1971]. Auf diese letztge- [Banga et al, 1954;C hvapil und Z ahradnik, 1960], ist bei der geringen Ausbildung von «crosslinks» im jungen Kollagen durchaus verständlich.…”

Section: Diskussionunclassified

“…Als Ur sache dieser im Alter zunehmenden Spannungskräfte wird die Ausbildung von intra-und intermolekularen Quervernetzungen ('crosslinks') [Verzär, 1963[Verzär, , 1964T raub und P iez, 1971;G allop et al, 1972;Bailey et al, 1974] angesehen. Die zur chemischen Denaturierung verwendeten Substanzen waren KJ [Banga et al, 1954], NaC104 [C hvapil und H ruza, 1959] und Harnstoff [E lden und Boucek, 1962], Boros-F arkas und E veritt [1967] [1964] verwiesen auf die bemerkenswert ein heitliche Wirkung der Anionen und Kationen der Hofmeisterschen Reihe, sowie von Harnstoff und Guanidinium-Cl auf Makromoleküle wie Kollagen bzw. Gelatine, Ribonuclease und DNA.…”

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Quellung von Kollagenfasern in Neutralsalzlösungen

Reitmayr¹

1976

Gerontology

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When applying various concentrations of NaCLO4 (0.15–7 m) to tendon fibres from rat tails, we found denaturation beginning at 2 m, and with increasing concentration a linear increase of the maximal contraction tension and an exponential shortening of the contraction time down to a minimal value of 7.5 min. In a second group of experiments we investigated the weight changes of tendons of old (26–30 months) and young (8 months) rats treated with 5 m NaCLO4 and compared the weight curves and the tension curves. We found an increase in weight up to 900% as the tension decreased. This indicates a connection between the swelling and the relaxation of collagen fibres. Other solutions of neutral salts (5 m NaCLO3, NaCl; 15 m NaCLO4, NaCLO3, NaCl) tested on young and old tendons did not produce any tension nor other visible changes. The weight curves show an immediate increase up to about 200% which remains constant and which is low compaired with the effect of 5 M NaCLO4. The reason for the contraction of tendon fibres seems to be the denaturation caused by the increased lipophilia of the aqueous salt solutions, while the relaxation is merely the result of the subsequent swelling of the collagen fibre.

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Section: Diskussionunclassified

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Quellung von Kollagenfasern in Neutralsalzlösungen

Reitmayr¹

1976

Gerontology

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“…The degree of contraction and relaxation of rat tail tendons under controlled conditions of temperature or osmolarity are directly dependent upon their biological age (1)(2)(3)(4)(5)(6).…”

Section: Warner-lambert Research Institute Morris Plains New Jerseymentioning

confidence: 99%

“…Several years ago Stuart and Biozzi (1) and their group were able to demonstrate significant changes in the phagocytic function of the reticuloendothelial system (RES) following intravenous administration of various esterified lipids. They found that ethyl esters of fatty acids such as ethyl stearate depressed phagocytosis whereas glyceryl esters such its trioleate enhanced phagocytosis.…”

Section: Arthur Berken~ and Baru J Benacerraf~mentioning

confidence: 99%