Contractile properties of hindlimb muscles in rat during surgical overload

Freeman, P.; Luff, A. R.

doi:10.1152/ajpcell.1982.242.5.c259

Cited by 12 publications

(6 citation statements)

References 18 publications

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“…It is well established that surgical and non-surgical increases in dynamically produced muscle tension result in larger muscles [14,[38][39][40][41], with increased force output [39][40][41][42][43][44][45], and our findings are consistent with these prior studies.…”

Section: Discussionsupporting

confidence: 92%

Muscle Force and Power Following Tendon Repair at Altered Tendon Length

Krochmal¹,

Kuzon²,

Urbanchek³

2008

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 92%

Muscle Force and Power Following Tendon Repair at Altered Tendon Length

Krochmal¹,

Kuzon²,

Urbanchek³

2008

Journal of Surgical Research

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“…This response is not unexpected because removal of the entire TA muscle has been shown to induce a corresponding approximate 20–25% increase in mass and P o of the EDL muscle over a 1-month period. 32–34 One concern then is the interpretation of in vivo functional measures if the EDL muscle is left intact since the net torque reflects the compensatory hypertrophy of the EDL muscle (Fig. 5).…”

Section: Discussionmentioning

confidence: 99%

A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies

Corona

Chen

et al. 2012

BioResearch Open Access

113

109

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Soft tissue injuries involving volumetric muscle loss (VML) are defined as the traumatic or surgical loss of skeletal muscle with resultant functional impairment and represent a challenging clinical problem for both military and civilian medicine. In response, a variety of tissue engineering and regenerative medicine treatments are under preclinical development. A wide variety of animal models are being used, all with critical limitations. The objective of this study was to develop a model of VML that was reproducible and technically uncomplicated to provide a standardized platform for the development of tissue engineering and regenerative medicine solutions to VML repair. A rat model of VML involving excision of ∼20% of the muscle's mass from the superficial portion of the middle third of the tibialis anterior (TA) muscle was developed and was functionally characterized. The contralateral TA muscle served as the uninjured control. Additionally, uninjured age-matched control rats were also tested to determine the effect of VML on the contralateral limb. TA muscles were assessed at 2 and 4 months postinjury. VML muscles weighed 22.7% and 19.5% less than contralateral muscles at 2 and 4 months postinjury, respectively. These differences were accompanied by a reduction in peak isometric tetanic force (Po) of 28.4% and 32.5% at 2 and 4 months. Importantly, Po corrected for differences in body weight and muscle wet weights were similar between contralateral and age-matched control muscles, indicating that VML did not have a significant impact on the contralateral limb. Lastly, repair of the injury with a biological scaffold resulted in rapid vascularization and integration with the wound. The technical simplicity, reliability, and clinical relevance of the VML model developed in this study make it ideal as a standard model for the development of tissue engineering solutions for VML.

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“…This could lead to the hypothesis that the slower intrinsic velocity of contraction is compensated by an increased number of serial sarcomeres. Freeman and Luff (1982) reported such an increase in the number of serial sarcomeres.…”

Section: Low Gravity Conditions and Limb Suspension And Bed Restmentioning

confidence: 92%

Adaptation of muscle size and myofascial force transmission: a review and some new experimental results

Huijing

Jaspers

2005

Scandinavian Med Sci Sports

128

106

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This paper considers the literature and some new experimental results important for adaptation of muscle fiber cross‐sectional area and serial sarcomere number. Two major points emerge: (1) general rules for the regulation of adaptation (for in vivo immobilization, low gravity conditions, synergist ablation, tenotomy and retinaculum trans‐section experiments) cannot be derived. As a consequence, paradoxes are reported in the literature. Some paradoxes are resolved by considering the interaction between different levels of organization (e.g. muscle geometrical effects), but others cannot. (2) An inventory of signal transduction pathways affecting rates of muscle protein synthesis and/or degradation reveals controversy concerning the pathways and their relative contributions. A major explanation for the above is not only the inherently limited control of the experimental conditions in vivo, but also of in situ experiments. Culturing of mature single Xenopus muscle fibers at high and low lengths (allowing longitudinal study of adaptation for periods up to 3 months) did not yield major changes in the fiber cross‐sectional area or the serial sarcomere number. This is very different from substantial effects (within days) of immobilization in vivo. It is concluded that overall strain does not uniquely regulate muscle fiber size. Force transmission, via pathways other than the myotendinous junctions, may contribute to the discrepancies reported: because of substantial serial heterogeneity of sarcomere lengths within muscle fibers creating local variations in the mechanical stimuli for adaptation. For the single muscle fiber, mechanical signalling is quite different from the in vivo or in vitro condition. Removal of tensile and shear effects of neighboring tissues (even of antagonistic muscle) modifies or removes mechanical stimuli for adaptation. It is concluded that the study of adaptation of muscle size requires an integrative approach taking into account fundamental mechanisms of adaptation, as well as effects of higher levels of organization. More attention should be paid to adaptation of connective tissues within and surrounding the muscle and their effects on muscular properties.

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Contractile properties of hindlimb muscles in rat during surgical overload

Cited by 12 publications

References 18 publications

Muscle Force and Power Following Tendon Repair at Altered Tendon Length

Muscle Force and Power Following Tendon Repair at Altered Tendon Length

A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies

Adaptation of muscle size and myofascial force transmission: a review and some new experimental results

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