Contraceptive Effect of Ethanolic Extract of Dioscorea villosa Tuber on Reproductive Hormones of Female Wistar Rats

Denen, Atsukwei; Daniel, Eze Ejike; Adams, Moses Dele; Tende, J.A.; Tope, Olaniyan Olugbemi; Danmallam, Lami

doi:10.9734/ijbcrr/2015/13433

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…The result revealed significant reduction of serum levels of progesterone by low dose (40 mg/kg) of Ficus sycomorus extract, and this effect might be as a result of inhibition of luteinizing hormone of the anterior pituitary (Blank et al, 2006). It could also be as a result of the alkaloids present in the plant which agrees with findings of Yakubu et al (2008) who reported that the alkaloid component of C. aconitifolious may be behind the reduction in serum progesterone levels, same was reported for the following plants with alkaloidal component: Senna alata leaves (Yakubu et al, 2010), Alchornea cordifolia (Lembe et al, 2014), Dioscorea villosa (Atsukwi, 2015). More so, alkaloids have been reported to inhibit the synthesis of cellular progesterone (Goize et al, 1996).…”

Section: Effect Of Ficus Sycomorus Extract On Serum Concentration Of supporting

confidence: 85%

Aphrodisiac effect of aqueous stem bark extract of<i>Ficus sycomorus </i>on female wistar rats

Tijjani¹,

Mabrouk²,

Yarube³

et al. 2019

Nig J Bas App Sci

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In the present study, the effect of aqueous stem bark extract of Ficus sycomorus was evaluated on female sex hormones and sexual behavior in female Wistar rats. Adult female rats having regular estrous cycle confirmed by daily cytology of the vaginal smear analysis were used. Rats were randomly divided into 3 groups (n=10): Group I served as a control; while group II, and III received 40 mg/kg and 80 mg/kg of the extracts respectively. The results revealed significant increase (p<0.5) in serum concentration of the estradiol in group II and a significant decrease (p<0.5) in serum concentration of estradiol in group III in comparison with the control. There was also significant decrease (p<0.5) in serum level of progesterone in group II and no significant effect in group III in comparison with the control. The result also indicated no significant effect (p>0.5) of the extract on female sexual behavior, which may suggest no scientific basis for the use of the extract as an aphrodisiac in females.

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Section: Effect Of Ficus Sycomorus Extract On Serum Concentration Of supporting

confidence: 85%

Aphrodisiac effect of aqueous stem bark extract of<i>Ficus sycomorus </i>on female wistar rats

Tijjani¹,

Mabrouk²,

Yarube³

et al. 2019

Nig J Bas App Sci

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“…15,16 Also reported that Species of Dioscorea has been also used as sources of saponins for the preparation of steroids in the pharmaceutical industry. Other similar study by, 17 is also confirmed that Dioscorea species is a popular herbal remedy for pains associated with rheumatism and arthritis, colic and intestinal cramps, proving itself a reliable antispasmodic and anti-inflammatory Figure 3. Moreover, many species of Dioscorea have many organic acids and polyphenols present in them and have antioxidant property.…”

Section: The Traditional Medicinal Use Of Dioscorea Spp In the Study supporting

confidence: 58%

Bio prospecting potentials of Dioscorea species in selected districts of Gedio and Sidama zones of SNNPR, Ethiopia

Seifu¹,

Misganaw²,

GirumFaris³

et al. 2018

JABB

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Abbreviations: SNNPR, south nation nationality people regional state; SPSS, statistical package for social science; ABS, access and benefit sharing; FAO, food and agriculture organization; GZFED, gedeo zone finance and economic development; SZFED, sidama zone finance and economic development. AbstractBio prospecting or biodiversity prospecting is the exploration, extraction and screening of biological diversity and indigenous knowledge for commercially valuable genetic and biochemical resources. Ethiopia is lucky to be gifted with rich biodiversity and traditional knowledge that could pioneer successful for bio-prospecting. Ethiopia holds a rich genetic diversity of tropical root and tuber crops which have tremendous medicinal and industrial potential. However, their bioprospecting potential for Access and Benefit Sharing has not been determined. Therefore, the objective of this study was to assess the bioprospecting potential of Dioscorea Species for Access and Benefit Sharing in selected districts of Gedio and Sidama Zones of SNNPR, Ethiopia. A total of 120 respondents, 10 from each kebeles were selected purposively to the semi structured interview. The results of this study showed that Dioscorea species is the most abundant among root crops in the study areas. It has several traditional medicinal uses such as stomach ache occur during delivery, itch, abscess, ringworm/fungal diseases, brain tumor, hypertension, stomach bloating and kidney infections. Based on the traditional use of Dioscorea species as base line and other related experimental studies, the essential extracts of Dioscorea species used by the local people of the study area might have industrial applications for pharmaceuticals, food and cosmetics industries for Access and Benefit sharing (ABS).

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Histopathological changes in placenta and liver of pregnant rats administered with aqueous extract of Dioscorea hispida var. daemona (Roxb) Prain & Burkill

Muhammad

Maslan

Saad

et al. 2019

Food and Chemical Toxicology

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Contraceptive Effect of Ethanolic Extract of Dioscorea villosa Tuber on Reproductive Hormones of Female Wistar Rats

Cited by 6 publications

References 26 publications

Aphrodisiac effect of aqueous stem bark extract of<i>Ficus sycomorus </i>on female wistar rats

Aphrodisiac effect of aqueous stem bark extract of<i>Ficus sycomorus </i>on female wistar rats

Bio prospecting potentials of Dioscorea species in selected districts of Gedio and Sidama zones of SNNPR, Ethiopia

Histopathological changes in placenta and liver of pregnant rats administered with aqueous extract of Dioscorea hispida var. daemona (Roxb) Prain & Burkill

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