Contraceptive effect of a gonadotropin-releasing hormone vaccine on a captive female African Lion (&lt;i&gt;Panthera leo&lt;/i&gt;): a case study

Kawase, Kazumi; Tomiyasu, Jumpei; Ban, Kanako; Ono, Ryosuke; Ando, Satoshi; Ono, Aya; Kimura, Ran; Tomisawa, Kanako; Matsui, Motozumi; Shiihara, Shun-ichi

doi:10.1292/jvms.21-0032

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…progestins implants [6], and vaccines [7]. Although reversible contraception is desirable since it permits natural social groupings to be preserved while maintaining the population's genetic health [2], surgical contraception has been utilized in animals with various pathologies and medical disorders and in animals that should not be bred [1].…”

Section: Introductionmentioning

confidence: 99%

Wound Retractor Laparoscopic Port System for Laparoscopic Ovariectomy in Panthera leo

Lacitignola

Laricchiuta²,

Imperante

et al. 2022

Animals

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The aim of this study was to assess the feasibility and intraoperative complications of performing ovariectomies in African lionesses (Panthera leo) using a wound retractor laparoscopic platform. Six lionesses (n = 6) were included. The surgical procedures were carried out through three portals, with a retractor platform positioned at the umbilical port and cannulas placed 3–4 cm from the cranial and caudal regions to the device at the level of the midline. An ovariectomy was performed with a vessel-sealing device. We evaluated the surgery time and the intraoperative and early postoperative complications. The mean weight was 172.83 kg. The total surgery time was 49.33 min. The installation step took a mean of 10.33 min to complete. The mean ovariectomy time was 20 min. Controlled bleeding was observed at the tip of the uterine horn in two cases due to excessive tissue thickness. The retrieval of dissected ovarian tissue and annexes was easily performed. No other complications were observed. The use of the laparoscopic platform during three-portal surgeries for laparoscopic ovariectomy in adult overweight lionesses is feasible and without intraoperative problems. The retractor meant that there were no entry-related issues due to the 25 mm mini-laparotomy. It also made it simpler to extract thick ovaries and promptly re-establish the pneumoperitoneum.

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Section: Introductionmentioning

confidence: 99%

Wound Retractor Laparoscopic Port System for Laparoscopic Ovariectomy in Panthera leo

Lacitignola

Laricchiuta²,

Imperante

et al. 2022

Animals

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Contraceptive effect of a gonadotropin‐releasing hormone vaccine on captive male brown bears (Ursus arctos)

Matsumoto,

Tomiyasu,

Hagino

et al. 2024

Reprod Domestic Animals

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Fertility control has traditionally been applied in zoos to control captive populations, and reversible contraception is important. However, contraceptive methods for male bears have not been reported. We aimed to establish a reversible contraceptive for male brown bears by investigating the effects of a gonadotropin‐releasing hormone (GnRH) vaccine (Improvac®) that was developed for the immune castration of pigs. We vaccinated six bears with two sequential doses of 400 (n = 2) or 600 μg Improvac® (n = 4) with a 1‐month interval during the pre‐breeding season (February to April). We compared the reproductive parameters (testosterone levels and semen parameters) of the six vaccinated and four non‐vaccinated (control) bears once during the breeding season (May or June). To investigate whether the reproductive performance could be restored in the following year of contraception, we also compared the reproductive parameters once during the breeding season in two bears between the year with GnRH vaccination and the following year without vaccination. Vaccination treatments suppressed reproductive parameters in 5 bears, although vaccination with 400 μg of Improvac® was not effective in one bear. Testosterone levels and the rate of progressive sperm motility were significantly lower, and total sperm count and testis size tended to be lower in vaccinated bears, compared with the controls. Blood biochemical findings and direct observations after Improvac® vaccination did not reveal side effects. Moreover, testosterone levels and spermatogenic scores of two bears were restored in the following year. We confirmed that the Improvac® vaccine elicited a reversible contraceptive effect in male brown bears.

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A new approach to the vasectomy of African lions ( Panthera leo )

Gazendam,

Monakali,

Landman

et al. 2023

Journal of the South African Veterinary Association

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Contraceptive effect of a gonadotropin-releasing hormone vaccine on a captive female African Lion (<i>Panthera leo</i>): a case study

Cited by 3 publications

References 19 publications

Wound Retractor Laparoscopic Port System for Laparoscopic Ovariectomy in Panthera leo

Wound Retractor Laparoscopic Port System for Laparoscopic Ovariectomy in Panthera leo

Contraceptive effect of a gonadotropin‐releasing hormone vaccine on captive male brown bears (Ursus arctos)

A new approach to the vasectomy of African lions ( Panthera leo )

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