“…As a result, each point in the volume significantly contributes to the detected signal. If, for example, we deal with absorbing inhomogeneities of tissues examined by pulsed probing with the time-domain measurement technique, integral (1), in the approximation of the perturbation theory by Born or Rytov, takes the form (Lyubimov et al, 2002;2003) is the distribution function of the absorbing inhomogeneities. Local linearization of the inverse problem of DOT is usually done with multi-step reconstruction algorithms based on the variational formulation of the radiation transport equation (or its diffusion approximation).…”