Continuum modeling of thrombus formation and growth under different shear rates

Rezaeimoghaddam, Mohammad; Vosse, F.N. van de

doi:10.1016/j.jbiomech.2021.110915

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…This may lead to DVT, increase the risk of surgery, affect the smooth surgery, and even endanger life. It can also lead to heart disease, high blood pressure, high blood fat, and many other diseases [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Computational Analysis of the Related Factors of Deep Vein Thrombosis (DVT) Formation in Patients Undergoing Hip Fracture Surgery

Zhou

Chen

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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A retrospective study was conducted on 51 patients undergoing hip fracture surgery to investigate the factors associated with the formation of deep venous thrombosis (DVT). The independent sample t-test and correlation analysis were used to sort out and analyze the data. The findings are as follows. (1) Different gender samples showed significant differences in the Caprini score and thrombus location. Most DVTs in females are located in the posterior tibial vein and intermuscular veins. The Caprini score of females was significantly higher than that of males. (2) Age displays a positive correlation with DVT, coronary heart disease, hypertension, and different surgical types, respectively. (3) There is a correlation between age and operation duration. (4) Hyperlipidemia and cerebrovascular disease show a positive correlation with DVT. (5) There was a significant negative correlation between the Caprini score and the quantification of D-dimer. This indicates that in this sample, the higher the patients’ Caprini score is, the lower the quantitation of D-dimer will be. (6) Hyperlipidemia and cardiac insufficiency show a positive correlation with cerebrovascular disease. Patients with hyperlipidemia and cardiac insufficiency may also suffer from cerebrovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Computational Analysis of the Related Factors of Deep Vein Thrombosis (DVT) Formation in Patients Undergoing Hip Fracture Surgery

Zhou

Chen

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Slow blood flow may result in the strong adhesion of lipids and other substances to the vascular wall, leading to thrombosis formation, vessel narrowing, and ultimately vessel occlusion 31 . Insufficient flow rate may impede the timely delivery of oxygen to the body through vascular scaffolds, resulting in inadequate nutrient supply to cells and ultimately compromising vascular transplantation success 32 . Increasing the flow rate can help to supply nutrients to the vascular scaffolds and remove waste products.…”

Section: Resultsmentioning

confidence: 99%

“…31 Insufficient flow rate may impede the timely delivery of oxygen to the body through vascular scaffolds, resulting in inadequate nutrient supply to cells and ultimately compromising vascular transplantation success. 32 Increasing the flow rate can help to supply nutrients to the vascular scaffolds and remove waste products. Figure 14 illustrates the vector diagram of blood flow in seven sections of the vascular scaffold channel with a thread structure of 0.2 mm at a flow rate of 0.1 m/s.…”

Section: Hydrogel Maximum Burst Pressurementioning

confidence: 99%

Design and preparation of an artificial vascular scaffold with internal surface modification

Jin,

Liu,

Nie

et al. 2024

Artificial Organs

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BackgroundAdvances in regeneration methods have brought us improved vascular scaffolds with small diameters (φ < 6 mm) for enhancing biological suitability that solve their propensity for causing intimal hyperplasia post‐transplantation.MethodsThe correlation between the rehydration ratio of the hydrogel and its material concentration is obtained by adjusting the material ratio of the hydrogel solution. The vascular model with helical structure has been established and analyzed to verify the effect of helical microvascular structure on thrombosis formation by the fluid simulation methods. Then, the helical structure vascular has been fabricated by self‐developed 3D bioprinter, the vascular scaffolds are freeze‐dried and rehydrated in polyethylene glycol (PEG) solution.ResultsThe experimental results showed that the hybrid hydrogel had a qualified rehydration ratio when the content of gelatin, sodium alginate, and glycerol was 5, 6, and 3 wt%. The established flow channel model can effectively reduce thrombus deposition and improve long‐term patency ratio. After PEG solution modification, the contact angle of the inner wall of the vascular scaffold was less than 30°, showing better hydrophilic characteristics.ConclusionIn study, a small‐diameter inner wall vascular scaffold with better long‐term patency was successfully designed and prepared by wrinkling and PEG modification of the inner wall of the vascular scaffold. This study not only creates small‐diameter vascular scaffolds with helical structure that improves the surface hydrophilicity to reduce the risk of thrombosis but also rekindles confidence in the regeneration of small caliber vascular structures.

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“…(C) Patient-specific 3D LA models of LA flow with thrombin concentration representing the thrombus (see also Supplementary video 1). area of interest in both clinical and engineering research fields (87)(88)(89).…”

Section: Hypercoagulabilitymentioning

confidence: 99%

“…This novel approach has informed subsequent studies in which thrombus growth influences blood flow velocity ( 78 , 85 , 86 ). The study of fibrin and thrombus growth dynamics is a continually growing area of interest in both clinical and engineering research fields ( 87 – 89 ).…”

Section: Imaging and Modelling Of Virchow’s Triadmentioning

confidence: 99%

Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

Qureshi

Lip

Nordsletten

et al. 2023

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial appendage (LAA) identified as the primary thromboembolic source. Current stroke risk stratification approaches, such as the CHA2DS2-VASc score, rely mostly on clinical comorbidities, rather than thrombogenic mechanisms such as blood stasis, hypercoagulability and endothelial dysfunction—known as Virchow’s triad. While detection of AF-related thrombi is possible using established cardiac imaging techniques, such as transoesophageal echocardiography, there is a growing need to reliably assess AF-patient thrombogenicity prior to thrombus formation. Over the past decade, cardiac imaging and image-based biophysical modelling have emerged as powerful tools for reproducing the mechanisms of thrombogenesis. Clinical imaging modalities such as cardiac computed tomography, magnetic resonance and echocardiographic techniques can measure blood flow velocities and identify LA fibrosis (an indicator of endothelial dysfunction), but imaging remains limited in its ability to assess blood coagulation dynamics. In-silico cardiac modelling tools—such as computational fluid dynamics for blood flow, reaction-diffusion-convection equations to mimic the coagulation cascade, and surrogate flow metrics associated with endothelial damage—have grown in prevalence and advanced mechanistic understanding of thrombogenesis. However, neither technique alone can fully elucidate thrombogenicity in AF. In future, combining cardiac imaging with in-silico modelling and integrating machine learning approaches for rapid results directly from imaging data will require development under a rigorous framework of verification and clinical validation, but may pave the way towards enhanced personalised stroke risk stratification in the growing population of AF patients. This Review will focus on the significant progress in these fields.

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Continuum modeling of thrombus formation and growth under different shear rates

Cited by 7 publications

References 37 publications

Computational Analysis of the Related Factors of Deep Vein Thrombosis (DVT) Formation in Patients Undergoing Hip Fracture Surgery

Computational Analysis of the Related Factors of Deep Vein Thrombosis (DVT) Formation in Patients Undergoing Hip Fracture Surgery

Design and preparation of an artificial vascular scaffold with internal surface modification

Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

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