Continuum modeling of mechano-dependent reactions in tissues composed of mechanically active cells

Stein, A.; Logvenkov, S. A.; Volodyaev, I.V.

doi:10.1016/j.biosystems.2018.09.010

Cited by 9 publications

(1 citation statement)

References 45 publications

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“…Tubulin dimers, and microtubules are now emerging as the constituents of a highly dynamic web, acting both as a source for the generation and the context for the interplay of physical energies[5,6]. These energies include mechanical forces[11-13] as well as the production of electric and very likely electromagnetic fields, with radiation characteristics[5,6,14], and even the occurrence of electromagnetic radiation (light), as a result of biophysical dynamics of a number of molecules increasingly regarded as chromophores[15-17]. To this end, the list of intracellular chromophores is now progressively increasing, including flavins, flavoproteins, and cytochromes[18-22], which are thought to be involved in the generation of reactive oxygen species (ROS) and nitric oxide[19,23-25], behaving as major pleiotropic conductors in cell biology.…”

Section: Introductionmentioning

confidence: 99%

Physical energies to the rescue of damaged tissues

Facchin

Canaider

Tassinari³

et al. 2019

WJSC

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Rhythmic oscillatory patterns sustain cellular dynamics, driving the concerted action of regulatory molecules, microtubules, and molecular motors. We describe cellular microtubules as oscillators capable of synchronization and swarming, generating mechanical and electric patterns that impact biomolecular recognition. We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores. We discuss the novel perspectives disclosed by mechanobiology, bioelectromagnetism, and photobiomodulation, both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern (stem) cell fate. We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation (light), respectively, generated by the stem cells across the specification of their multilineage repertoire. The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells in situ , where they already are resident in all the tissues of the human body. We discuss how this strategy may pave the way to a regenerative and precision medicine without the needs for (stem) cell or tissue transplantation. We describe a novel paradigm based upon boosting our inherent ability for self-healing.

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