Continuous use of metformin in patients receiving contrast medium: what is the evidence? A systematic review and meta-analysis

Renal Complications after Percutaneous Coronary Interventions on Concurrent Metformin Therapy: A Systematic Review with Meta-Analysis

“…14 This has caused considerable controversy, with many investigators challenging this approach, based on the absence of solid data, especially in patients without co-morbidities. [15][16][17] Therefore, the European Society of Urogenital Radiology recommend no need to discontinue metformin in patients with estimated glomerular filtration rate (eGFR) ≥ 30 ml/ min/1.73m 2 and no sign of acute kidney injucry, receiving intra-arterial CM with second pass renal exposure. 18 However, previous analyses have included studies examining both intravenous and intra-arterial administration, although the risk of CIN in the latter appears higher.…”