Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen

Vercellini, Paolo; Frontino, Giada; Giorgi, Olga De; Pietropaolo, Giuliana; Pasin, Roberta; Crosignani, Pier Giorgio

doi:10.1016/s0015-0282(03)00794-5

Cited by 248 publications

(156 citation statements)

References 4 publications

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“…As previously found in other studies [2,10,34,35], we observed a significant reduction in the risk of postoperative endometrioma recurrence in patients who underwent laparoscopic excision and long-term postoperative use of cyclic OCs, compared with patients who did not receive such treatment.…”

Section: Discussionsupporting

confidence: 89%

“…Other authors have pointed out that long-term cyclic and continuous OCs use effectively reduces and delays recurrence [2,10]. Long-term exposure to OCs has been associated with a greater reduction in the risk of recurrence, which is directly proportional to the duration of therapy [35]. In our sample of patients, postoperative OCs treatment was administered long term.…”

Section: Discussionmentioning

confidence: 81%

“…Furthermore, we chose cyclic administration because it was more easily accepted by patients from the psychological standpoint, since it results in a regular cycle. In literature, a positive trend has also been reported in patients receiving continuous therapy [2,35]. This may be due to its constant hormonal environment, which could increase the effectiveness of the therapy [35].…”

Section: Discussionmentioning

confidence: 95%

“…The mechanisms reported above have been the subject of recent studies that assess the effectiveness of long-term OCs administration in preventing ovarian endometrioma recurrence [2], thus offering a valuable alternative to serial surgery [24,34,35]. A recent randomized controlled trial [36] examined the effect of postoperative OCs on endometrioma recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Cucinella

Granese²,

Calagna

et al. 2013

Arch Gynecol Obstet

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Objective The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative longterm regimen of oral contraceptives (OCs). Materials and methods 168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transvaginal scan were planned at 1, 3, 6, 12, and 24 months after surgery. All patients who showed an ultrasound persistence of the endometrioma at 1 month follow-up were excluded from clinical analysis.Results Of the 168 patients, 131 completed the 24 months follow-up. Endometrioma recurrence was found in 21 (12.5 %) of all patients, it was unilateral in 17 cases while bilateral in 4 cases. The rate of recurrent endometrioma was statistically significant in non-users compared to the long-term OCs treated patients. Conclusion The current data suggest the usefulness of long-term OCs regimen after conservative surgery for the prevention of ovarian endometrioma recurrence. As a statistical significant difference could not be observed between OCs groups, further study on the individual molecules is required in order to really understand the effect of each of them.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Cucinella

Granese²,

Calagna

et al. 2013

Arch Gynecol Obstet

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“…While six-month administration of postoperative OC did not significantly reduce pain recurrence, a delay in the recurrence of pain was evident. A clinical trial (Vercellini et al 2003) reported that long-term continuous OC can be used in women with endometriosis-associated recurrent dysmenorrhea that does not respond to cyclic OC use after surgical treatment.…”

Section: Combination Management 1) Post-operative Administration Omentioning

confidence: 99%

Management of the Pain Associated with Endometriosis: An Update of the Painful Problems

Ozawa

Murakami

Yaegashi

et al. 2006

Tohoku J. Exp. Med.

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Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception

Edelman

Gallo²,

Jensen

et al. 2005

Cochrane Database of Systematic Reviews

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Evidence from existing randomized control trials comparing COCs given continuously (greater than 28 days of active pills) to traditional monthly cyclic dosing (21 days of active pills and 7 days of placebo) is of good quality. However, the variations in type of pill and time length for continuous dosing make direct comparisons between regimens impossible. Future studies should choose a previously described type of pill and dosing regimen. More attention needs to be directed towards participant satisfaction and menstruation-associated symptoms.

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Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen

Cited by 248 publications

References 4 publications

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Management of the Pain Associated with Endometriosis: An Update of the Painful Problems

Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception

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