Continuous Topical Oxygen for the Treatment of Chronic Wounds

Woo, Kevin; Coutts, Patricia; Sibbald, R. Gary

doi:10.1097/01.asw.0000423439.62789.90

Cited by 26 publications

(12 citation statements)

References 17 publications

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“…71 The lack of a formal study in this regard has been offset by several reviews, case series, and experimental studies on the effect of topically administered oxygen at the wound surface that seem to indicate a benefit in promoting wound repair. 154,[159][160][161][162][163][164][165][166][167][168][169] While several RCTs with different devices have been ongoing, there have been no publications to date comparing 12-week healing rates with those of standard care.…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,712

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,712

1,429

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“…Malodour was used in 25 studies with a total of 1298 CLUs and erythema was used in 25 studies with 811 CLUs 12,14,22,34,37,38,41,45,47,50,51,[53][54][55][56][57][58][59][60][61][62][63][64][65][66] (Table 4). Malodour has been used in combination with other clinical signs 41,58,62 and/or microbial indicators. 45,[67][68][69] However, in a study that investigated the roles of specific bacteria in wound malodour production between 43 infected and 30 non-infected leg ulcers, the authors found malodour presented in both infected (18.6%) and non-infected leg ulcers (6.7%), (level III),.…”

Section: How Have Clinical Signs and Symptoms Of Infection Been Usementioning

confidence: 99%

“…Oedema was used in 22 studies with a total of 484 CLUs. 12,14,22,37,38,41,47,48,50,[54][55][56][57][58][59][60]62,73 Seventeen studies used increased temperature around the wound or warmth or hot to touch to diagnose infection in nearly 250 CLUs. Seventeen reviewed studies used delayed healing to diagnose infection in 181 CLUs, five studies used increased ulcer area in almost 500 CLUs, and wound breakdown was also used in five studies with almost 200 CLUs.…”

Section: How Have Clinical Signs and Symptoms Of Infection Been Usementioning

confidence: 99%

The diagnosis of infection in chronic leg ulcers: A narrative review on clinical practice

Bui

Finlayson

Edwards

2019

International Wound Journal

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This literature review aimed to provide a narrative review of evidence on validity of clinical and microbial indicators of infection and to gain insights into the diagnosis of infection in chronic leg ulcers (CLUs). A search was conducted in Cinahl, Medline, the Cochrane Library databases, Embase, Web of Science, ScienceDirect, Pubmed, PsycINFO, ProQuest dissertations, and Google Scholar from January 1990 to July 2017. The inclusion criteria were original studies, systematic reviews, and consensus documents focused on “infection” in CLUs, English language, clinical and community settings, and human. The reviewed studies were inconsistent in criteria for infection between investigated wound types and lack of specificity regarding wound types. There were few studies investigating the criteria for diagnosis of infection in leg ulcers. The identification of leg ulcer infection still remains problematic and relies on out‐of‐date and not uniform evidence. Literature in this area was mostly limited to level III and IV evidence based on The Australian National Health and Medical Research Council Levels of Evidence, or expert opinion. This literature review showed seven clinical signs and symptoms that could be diagnostic for infection in CLUs, including: new, increased, or altered ulcer pain; malodour; increased ulcer area; wound breakdown, delayed or non‐healing; and erythema and increased local temperature, whilst the microbial indicators used to diagnose infected leg ulcers were varied and regarded as less important.

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“…12 These results have been validated in small cohorts of chronic wound patients, where the wounds experienced some healing during treatment. 14–16 …”

Section: Introductionmentioning

confidence: 99%

A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy

Copeland¹,

Purvis²

2017

Advances in Wound Care

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Objective: Topical oxygen devices are Food and Drug Administration (FDA) cleared for the following indications for use of various etiologies: skin ulcerations due to diabetes, venous stasis, postsurgical infections and gangrenous lesions, decubitus ulcers; amputations/infected stumps; skin grafts; burns; and frostbite. The goal of this study was to understand the impact of topical oxygen therapy (TOT) on patient outcomes, including amputation and healing rates.Approach: This retrospective chart review included records collected between January 1, 2007, and July 18, 2016, from male and female patients ranging in age from 4 years to 105 years. All wounds were at least 1 cm2 and were treated with at least one separate modality before treatment with TOT and then treated with TOT for a minimum of 2 weeks in compliance with the FDA-approved indications. All records were from wounds that were no longer being treated with TOT.Results: In this study, TOT was associated with an overall rate of 59.4% for a reduction in chronic wound size, while 41.6% of wounds had no healing. The overall amputation rate was 2.4% for wounds in this study.Innovation: To our knowledge, this retrospective chart review represents one of the largest data sets (4,127 total wounds) collected over one of the longest time periods (9.5 years) to evaluate patient outcomes following TOT.Conclusion: This study revealed healing and amputation rates similar to those reported in controlled clinical studies using TOT to treat chronic wounds.

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Continuous Topical Oxygen for the Treatment of Chronic Wounds

Cited by 26 publications

References 17 publications

Challenges in the Treatment of Chronic Wounds

Challenges in the Treatment of Chronic Wounds

The diagnosis of infection in chronic leg ulcers: A narrative review on clinical practice

A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy

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