Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation

Liu, Dong-Xu; Xia, He; Wu, Dan; Zhang, Qun; Yang, Chao; Liang, Fengyin; He, Xiaofei; Dai, Guangyan; Pei, Zhong; Lan, Yue; Xu, Gelin

doi:10.1016/j.neulet.2017.05.064

Cited by 48 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies in both human and animal models have found increased Aβ levels after sleep deprivation [52,53], and recent findings described that some genetic variations of AQP4 can directly modify sleep quality and influence the clearance of Aβ [50]. However, sleep-deprived mice have also been shown to suffer AQP4 depolarisation [54], indicating that sleep, in turn, influences AQP4.…”

Section: Aqp4 and Tau Proteinmentioning

confidence: 99%

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Silva

Ferreira

et al. 2021

Neurol. Res. Pract.

100

View full text Add to dashboard Cite

Lacking conventional lymphatic system, the central nervous system requires alternative clearance systems, such as the glymphatic system, which promotes clearance of interstitial solutes. Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer’s disease (AD). The clearance of Alzheimer’s associated proteins amyloid β and tau is diminished by glymphatic system impairment, due to lack of AQP4. Even though AQP4 mislocalisation (which affects its activity) is a phenotype of AD, it remains a controversial topic, as it is still unclear if it is a phenotype-promoting factor or a consequence of this pathology. This review provides important and updated knowledge about glymphatic system, AQP4 itself, and their link with Alzheimer’s disease. Finally, AQP4 as a therapeutic target is proposed to ameliorate Alzheimer’s Disease and other neuropathologies AQP4-related.

show abstract

Section: Aqp4 and Tau Proteinmentioning

confidence: 99%

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Silva

Ferreira

et al. 2021

Neurol. Res. Pract.

100

View full text Add to dashboard Cite

show abstract

“…By measuring the lactate concentration in the brains and cervical lymph nodes of awake and sleeping mice, Lundgaard et al ( 2017 ) demonstrated that lactate can exit the CNS via the paravascular pathway. Their analysis took advantage of the substantiated hypothesis that glymphatic function is promoted during sleep (Xie et al, 2013 ; Lee et al, 2015 ; Liu et al, 2017 ). In another study, Iliff et al ( 2014 ) showed that tau, a protein implicated in progressive neurodegenerative diseases, is also cleared by this pathway.…”

Section: Function and Significance Of The Paravascular Pathwaymentioning

confidence: 99%

The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy

et al. 2017

View full text Add to dashboard Cite

The paravascular pathway, also known as the “glymphatic” pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the brain, mixes with interstitial fluid (ISF) and solutes in the parenchyma, and exits along paravascular spaces of draining veins. Studies have shown that metabolic waste products and solutes, including proteins involved in the pathogenesis of neurodegenerative diseases such as amyloid-beta, may be cleared by this pathway. Consequently, a growing body of research has begun to explore the association between glymphatic dysfunction and various disease states. However, significant controversy exists in the literature regarding both the direction of waste clearance as well as the anatomical space in which the waste-fluid mixture is contained. Some studies have found no evidence of interstitial solute clearance along the paravascular space of veins. Rather, they demonstrate a perivascular pathway in which waste is cleared from the brain along an anatomically distinct perivascular space in a direction opposite to that of paravascular flow. Although possible explanations have been offered, none have been able to fully reconcile the discrepancies in the literature, and many questions remain. Given the therapeutic potential that a comprehensive understanding of brain waste clearance pathways might offer, further research and clarification is highly warranted.

show abstract

“…In summary, we speculate that reduced clearance of metabolic waste due to impaired glymphatic pathways is a major contributor to the development of PSCI and an impediment to the recovery of cognitive function. Alternatively, previous animal studies by our research team have con rmed that cTBS can improve the clearance e ciency of glymphatic pathways in mice [35] . Therefore, we speculate that cTBS may improve cognitive function in PSCI patients by enhancing glymphatic clearance.…”

Section: Discussionmentioning

confidence: 90%

Efficacy of Continuous Theta Burst Stimulation on Brain Clearance Recovery in Post-stroke Cognitive Impairment

Huang

Jing

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Cognitive impairment is a frequent and often debilitating consequence of stroke. This single-blinded randomized controlled trial examined the therapeutic benefits of continuous theta burst stimulation (cTBS) for patients with post-stroke cognitive impairment (PSCI). Methods: Twenty patients with PSCI were randomly and equally allocated to cTBS and sham cTBS groups. Groups received the indicated treatments five consecutive days per week for 2 weeks (10 sessions) plus 10 sessions of computer-assisted cognitive training. The primary outcomes were changes in Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) score and analysis along the perivascular space (ALPS) index. Results: The post-intervention change in ADAS-cog score from baseline was significantly greater in the cTBS group than the sham cTBS group (-7.7 ± 3.8 vs. -3.7 ± 1.5, t = -3.096, P = 0.006). Change in ALPS index from baseline was also greater in the cTBS group (0.182 ± 0.097 vs. 0.093 ± 0.080, t = 2.236, P = 0.038). Conclusion: Continuous theta burst stimulation can improve cognitive outcome and enhance ALPS. Enhanced waste clearance via the glymphatic system induced by cTBS may contribute to improved cognitive function following stroke.Clinical Trial Registration URL: http://www.chictr.org.cn. ChiCTR1800017997. Registered August 25, 2018, retrospectively registered.

show abstract

Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation

Cited by 48 publications

References 28 publications

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy

Efficacy of Continuous Theta Burst Stimulation on Brain Clearance Recovery in Post-stroke Cognitive Impairment

Contact Info

Product

Resources

About