Continuous Tcr Signaling In The Atherosclerotic Environment Induces Immunomodulatory Cd8+ T-Cells Expressing Cd39

Abstract

Background and Aims: Abdominal aortic aneurysms (AAA) have a multifactorial pathology with both genetic and environmental risk factors. Genome-wide association studies have discovered nine genetic risk loci for AAA. Our aim was to investigate to what extent these genetic variants contribute to the aneurysm pathology.