Continuous supercritical CO2 assisted process for the production of nano-niosomes loaded with a second-generation antibiotic for ocular therapy

Baldino, Lucia; Reverchon, Ernesto

doi:10.1016/j.supflu.2022.105673

Cited by 12 publications

(16 citation statements)

References 37 publications

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“…305, Villiers Le Bel, France). The contact between the ethanolic solution of lipids and SC-CO 2 promotes the formation of a gas-expanded liquid [ 15 , 16 , 18 , 19 , 20 ] that is delivered through a capillary tube (8 cm length, 1/8 in. external diameter, 0.028 in.…”

Section: Methodsmentioning

confidence: 99%

“…A continuous supercritical CO 2 (SC-CO 2 ) assisted process, named SuperSomes [ 15 ], has been proposed for vesicle production with the aim of overcoming the previously described limits. Using a versatile lab-scale plant, liposomes and niosomes of nanometric size, characterized by high encapsulation efficiencies (greater than 85%) of different drugs [ 15 , 16 ], have been obtained.…”

Section: Introductionmentioning

confidence: 99%

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Production of Antioxidant Transfersomes by a Supercritical CO2 Assisted Process for Transdermal Delivery Applications

Squittieri,

Baldino,

Reverchon

2023

Nanomaterials

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Transfersomes are deformable vesicles that can transport drugs across difficult-to-permeate barriers in human tissues. In this work, nano-transfersomes were produced for the first time by a supercritical CO2 assisted process. Operating at 100 bar and 40 °C, different amounts of phosphatidylcholine (2000 and 3000 mg), kinds of edge activators (Span® 80 and Tween® 80), and phosphatidylcholine to edge activator weight ratio (95:5, 90:10, 80:20) were tested. Formulations prepared using Span® 80 and phosphatidylcholine at an 80:20 weight ratio produced stable transfersomes (−30.4 ± 2.4 mV ζ-potential) that were characterized by a mean diameter of 138 ± 55 nm. A prolonged ascorbic acid release of up to 5 h was recorded when the largest amount of phosphatidylcholine (3000 mg) was used. Moreover, a 96% ascorbic acid encapsulation efficiency and a quasi-100% DPPH radical scavenging activity of transfersomes were measured after supercritical processing.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Production of Antioxidant Transfersomes by a Supercritical CO2 Assisted Process for Transdermal Delivery Applications

Squittieri,

Baldino,

Reverchon

2023

Nanomaterials

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“…Baldino and Reverchon (2022) prepared nano-niosomes by a continuous supercritical CO 2 assisted process [ 69 ]. These liposomes are used for the treatment of bacterial conjunctivitis.…”

Section: Vesicular Systemsmentioning

confidence: 99%

“…In studies regarding niosomes, various production methodologies have been identified, including TFH, the continuous supercritical CO 2 process, reverse-phase evaporation, and ethanol injection [ 5 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. The resulting niosomes from these methods have shown EE percentages ranging from 40% to 90% [ 75 ].…”

Section: Vesicular Systemsmentioning

confidence: 99%

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Batur,

Özdemir,

Durgun

et al. 2024

Pharmaceuticals

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Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for ocular drug delivery. These include improved drug bioavailability, prolonged retention time on the ocular surface, reduced systemic side effects, and protection of drugs from enzymatic degradation and dilution by tears. Moreover, vesicular formulations can be engineered for targeted delivery to specific ocular tissues or cells, enhancing therapeutic efficacy while minimizing off-target effects. They also enable the encapsulation of a wide range of drug molecules, including hydrophilic, hydrophobic, and macromolecular drugs, and the possibility of combination therapy by facilitating the co-delivery of multiple drugs. This review examines vesicular drug delivery systems, their advantages over conventional drug delivery systems, production techniques, and their applications in management of ocular diseases.

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“…Moreover, throughout a depressurization line, the organic solvent can be completely removed and recovered in a separator vessel because of the solubility of ethanol in SC-CO 2 [ 58 , 59 ]. This one-shot process allows the production of large volumes of vesicle suspension and can be used to form liposomes [ 58 , 59 ], niosomes [ 60 , 61 ] and transfersomes [ 62 ] characterized by high drug encapsulation efficiency, even more than 90%, good control on vesicle size, size distribution and morphology, and does not require further downstream steps of particle reduction or purification [ 63 ].…”

Section: Production Of Nanovesiclesmentioning

confidence: 99%

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi,

Baldino,

Reverchon

2024

J Transl Med

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One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limitations related to the conventional vaccination strategies, such as low safety, necessity of multiple injection, and side effects. However, due to the instability of pristine antigen, RNA and DNA molecules, the use of nanocarriers is required. Among the different nanocarriers proposed for vaccinal applications, three types of nanovesicles were selected and analysed in this review: liposomes, transfersomes and niosomes. PubMed, Scopus and Google Scholar databases were used for searching recent papers on the most frequently used conventional and innovative methods of production of these nanovesicles. Weaknesses and limitations of conventional methods (i.e., multiple post-processing, solvent residue, batch-mode processes) can be overcome using innovative methods, in particular, the ones assisted by supercritical carbon dioxide. SuperSomes process emerged as a promising production technique of solvent-free nanovesicles, since it can be easily scaled-up, works in continuous-mode, and does not require further post-processing steps to obtain the desired products. As a result of the literature analysis, supercritical carbon dioxide assisted methods attracted a lot of interest for nanovesicles production in the vaccinal field. However, despite their numerous advantages, supercritical processes require further studies for the production of liposomes, transfersomes and niosomes with the aim of reaching well-defined technologies suitable for industrial applications and mass production of vaccines.

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Continuous supercritical CO2 assisted process for the production of nano-niosomes loaded with a second-generation antibiotic for ocular therapy

Cited by 12 publications

References 37 publications

Production of Antioxidant Transfersomes by a Supercritical CO2 Assisted Process for Transdermal Delivery Applications

Production of Antioxidant Transfersomes by a Supercritical CO2 Assisted Process for Transdermal Delivery Applications

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

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