Continuous subcutaneous insulin infusion (CSII) does not prevent progression of proliferative and preproliferative retinopathy.

Lawson, P; Champion, M C; Canny, Christopher; Kingsley, Ronald; White, Michael C.; Dupré, J.; Kohner, Eva M.

doi:10.1136/bjo.66.12.762

Cited by 66 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 8 centres where baseline fasting glucose was measured, incident SVI was twice as high in those in the top third of the glucose distribution as in the lower two thirds. The importance of hyperglycaemia in the incidence of retinopathy and the progression of mild to moderate retinopathy was highlighted by DCCT [38] though its late stages are likely to be increasingly influenced by other determinants [39,40] particularly by the retinovascular damage itself.…”

Section: Discussionmentioning

confidence: 99%

The incidence of visual impairment and its determinants in the WHO multinational study of vascular disease in diabetes

Miki

Lee

et al. 2001

Diabetologia

View full text Add to dashboard Cite

In industrial societies more than 12 % of new cases of blindness are attributable to diabetes and the risk of blindness is about 30 times higher in people with diabetes than in the general population [1,2, 3]. The WHO Multinational Study of Vascular Disease in Diabetes (WHO MSVDD), designed to compare the vascular complications of diabetes in different ethnic groups using standardised methods, included an estimate of visual function in the baseline assessment [28]. This was repeated in the follow-up study [4], conducted at 10 of the original 14 centres, providing an opportunity to ascertain incidence and progression of visual impairment and its risk factors in these cohorts. Diabetologia (2001) Methods. Visual function was ascertained at followup in 2994 (77.9 %) of the 3845 eligible participating survivors of the 4709 originally recruited for the WHO MSVDD using the same baseline enquiry method. The associations between incident severe visual impairment, follow-up prevalence of all grades of impairment and baseline risk factors were examined by univariate and stepwise multiple logistic regression analysis. Results. Overall, 8.4 year incidence of severe visual impairment was 1.94 % and showed statistically significant univariate correlations with age at diagnosis, diabetes duration, systolic blood pressure, fasting blood glucose and cholesterol, insulin treatment and strongly with baseline retinopathy. Baseline retinopathy, systolic pressure and cholesterol were statistically significant in multivariable analysis. Differences between centres (0.3 % to 3.45 %) were not significant. Ultimate prevalence of all grades of impairment differed between centres and within almost all of them was correlated in multivariable analysis with baseline retinopathy and proteinuria. Conclusion/interpretation. Comparisons of incident severe visual impairment between centres are restricted by selective mortality, low incidence rates and relatively small numbers in each centre but before retinopathy, baseline systolic pressure and cholesterol predicted severe visual impairment. Followup prevalence of all degrees of impairment varied among centres and were associated with prior retinopathy and renal disease at baseline. [Diabetologia (2001)

show abstract

Section: Discussionmentioning

confidence: 99%

The incidence of visual impairment and its determinants in the WHO multinational study of vascular disease in diabetes

Miki

Lee

et al. 2001

Diabetologia

View full text Add to dashboard Cite

show abstract

“…Some patients still progress to worsening retinopathy even with improved blood sugar control. [7][8][9] The vision of many patients could be preserved, at least for a longer period, if earlier treatments were available.…”

mentioning

confidence: 99%

Multifocal Electroretinograms Predict Onset of Diabetic Retinopathy in Adult Patients with Diabetes

Harrison¹,

Bearse²,

et al. 2011

Invest. Ophthalmol. Vis. Sci.

183

142

View full text Add to dashboard Cite

show abstract

“…When close monitoring of glycaemia and methods of giving frequent insulin injections became possible in routine practice clinicians had great expectations that similarly strict control in humans could prevent the development of diabetic retinopathy and arrest or even reverse early lesions. These expectations were dashed, however, when it became clear that tightening control in patients with existing retinopathy could make the lesions worse 2. This normoglycaemic re-entry phenomenon has puzzled clinicians,3 and, although there is still much to learn about its mechanism, it is becoming clearer how to manage it.…”

mentioning

confidence: 99%

Why some cases of retinopathy worsen when diabetic control improves

Chantelau

Kohner

1997

BMJ

Self Cite

View full text Add to dashboard Cite

Continuous subcutaneous insulin infusion (CSII) does not prevent progression of proliferative and preproliferative retinopathy.

Cited by 66 publications

References 9 publications

The incidence of visual impairment and its determinants in the WHO multinational study of vascular disease in diabetes

The incidence of visual impairment and its determinants in the WHO multinational study of vascular disease in diabetes

Multifocal Electroretinograms Predict Onset of Diabetic Retinopathy in Adult Patients with Diabetes

Why some cases of retinopathy worsen when diabetic control improves

Contact Info

Product

Resources

About