Continuous, simultaneous and instantaneous tissue gas and blood flow measurements using the mass spectrometer

Abstract

Using a membrane permeable to gases it has been demonstrated in our laboratory that partial pressures of O2, CO2 and N2 can be monitored continuously, simultaneously and instantaneously employing a mass spectrometer. Physiologic studies in experimental animals have been carried out recording tissue gases from kidney, liver, skin and brain. Responses in these organs to changes in blood flow, blood gases, surgical trauma, and isolated perfusion have been conducted. Blood flow can be calculated by adding an inert gas (Argon) to the ventilation mixture, and recording its washout time. Simultaneous pO2, pCO2 and PAr permits focal metabolic studies previously impossible to record.