Continuous protein-density gradients: A new approach to correlate physical cues with cell response
Shanshan Zhang,
Oliver Felthaus,
Lukas Prantl
et al.
Abstract:To assess cellular behavior within heterogeneous tissues, such as bone, skin, and nerves, scaffolds with biophysical gradients are required to adequately replicate the in vivo interaction between cells and their native microenvironment. In this study, we introduce a strategy for depositing ultrathin films comprised of laminin-111 with precisely controlled biophysical gradients onto planar substrates using the Langmuir–Blodgett (LB) technique. The gradient is created by controlled desynchronization of the barri… Show more
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