Continuous Progestogen Contraception: A Dose Relationship Study with Chlormadinone Acetate

Martínez-Manautou, J; Giner-Velasquez, J.; Rudel, Harry W.

doi:10.1016/s0015-0282(16)36185-4

Cited by 39 publications

(4 citation statements)

References 2 publications

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“…T h e explanation for these findings may be that both C M V and LAP activity are hormonal dependent. Estrogen causes an increase in LAP activity and a decrease in C M V (3,13), while progesterone inhibits the LAP response to estrogen and increases C M V (10,13). An increase in LAP activity was observed 24 hours after estrogen administration and reached a peak 72 hours later (13).…”

Section: Discussionmentioning

confidence: 97%

The Value of Simple Tests in the Detection of Human Ovulation

Lotan

Diamant

1979

Intl J Gynecology & Obste

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Cervical mucus viscosity (CMV) and fern test (FT), leukocyte alkaline phosphatase (LAP) activity, basal body temperature (BBT) and serum luteinizing hormone (LH) levels were determined during 31 normal menstrual cycles of 29 volunteers. The day of the serum LH surge was taken as a reference point in evaluating the reliability and sensitivity in predicting ovulation of the other tests studied. Serum LH surge was accompanied by a sudden decrease in CMV, an increase in LAP activity, a gradual increase in FT and biphasic changes of BBT. In about 95% of cycles studied, the lowest values of CMV and peak values of LAP activity appeared on the day of the serum LH surge or one day before or one day after. The lowest point of the BBT coincided with the LH surge in only 26% of cycles. In 53% of cycles, the span was greater than one day before or after the LH peak. The FT corresponded to the LH surge in only 33% of the cycles, while in an additional 33% the preovulatory FT response occurred more than one day before or after the LH surge. The results indicate that CMV and LAP tests are rapid, simple and reliable for monitoring follicular maturation and the timing of ovulation when carried out daily, and may be of value in monitoring treatment during the induction of ovulation.

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Section: Discussionmentioning

confidence: 97%

The Value of Simple Tests in the Detection of Human Ovulation

Lotan

Diamant

1979

Intl J Gynecology & Obste

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“…However, human clinical experi ence confi rms that low doses of progestagen change the consistency of cer vical mucus, making it hard for the spermatozoa to penetrate, while possibly at the same time inhibiting the transport of such spermatozoa as arrive in the uterus. The progestagen may be given by injection (34,35) or orally (36). Menstruation occurs naturally and side effects appear to be minimal.…”

Section: Inhibition Of Fertilisationmentioning

confidence: 99%

Antifertility Agents

Emmens¹

1970

Annu. Rev. Pharmacol.

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“…The idea of contraception without inhibition of ovulation was introduced in 1965 by Rudel, Martinez-Manautou & Maqueo-Topete. Their studies led to the development of a contraceptive regimen based on continuous administration of synthetic progestogens, in low dosage without added oestrogen (Martinez-Manautou, Cortez, Giner, Aznar, Casasola & Rudel, 1966; Martinez-Manautou, Giner-Velasquez, Cortez-Gallegos, Aznar, Rojas, Guittenez-Najar & Rudel, 1967a; Martinez-Manautou, Giner-Velasquez & Rudel, 1967b). Many successful trials of this regimen using various progestogens including megestrol acetate have now been reported by other groups of workers (Mason, Cox, Mason & Grant, 1967;Macdonald, Lumley, Coulson & Stitch, 1968;Foss, Svendsen, Fotherby & Richards, 1968; Zanartu, Rodriguez, Pupkin, Salas & Guerrero, 1968b;Howard, Elstein, Blair & Morris, 1969;Mears, Vessey, Andolsek & Oven, 1969;Cox, 1969).…”

Section: Introductionmentioning

confidence: 99%

Investigations into the mechanism of the antifertility action of minimal doses of megestrol acetate in the rabbit

Ke¹,

Jm²

1970

British J Pharmacology

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Summary . Experiments have been performed to investigate the mechanism by which low doses of megestrol acetate have an antifertility action. . It was found that the dose of megestrol acetate required to prevent pregnancy in nine of ten New Zealand White rabbits when given on 3 consecutive days, the last of which was the day of insemination, was 50 μg/kg daily. . This treatment reduced the numbers of sperm recoverable from the uterus at various times after insemination, but egg transfer experiments showed that neither egg viability nor fertilization was affected on day 1 of pregnancy. . Treatment with megestrol acetate for 3 days caused the fertilized eggs to enter the uterus approximately 48 h prematurely. Treatment with megestrol acetate for longer periods caused a similar but more marked increase in the rate of transport of eggs in the oviduct. . Megestrol acetate did not modify oviduct opening pressure, but the volume of oviduct fluid secretion was reduced earlier and transport of fluid through the oviduct was accelerated compared with controls. . Transfer of eggs on various days from the uteri of untreated rabbits to the uteri of treated rabbits indicated that the development of the endometrium which occurs in pregnancy may be advanced by megestrol administration. Histological examination of the endometrial proliferation induced by megestrol acetate confirmed that this was so. . It is concluded that the antifertility action of megestrol acetate in doses that do not necessarily inhibit ovulation is due to a combination of accelerated egg transport and advanced endometrial development.

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Continuous Progestogen Contraception: A Dose Relationship Study with Chlormadinone Acetate

Cited by 39 publications

References 2 publications

The Value of Simple Tests in the Detection of Human Ovulation

The Value of Simple Tests in the Detection of Human Ovulation

Antifertility Agents

Investigations into the mechanism of the antifertility action of minimal doses of megestrol acetate in the rabbit

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