Continuous positive airway pressure therapy suppresses inflammatory cytokines and improves glucocorticoid responsiveness in patients with obstructive sleep apnea and asthma: A case–control study

Mahboub, Bassam; Kharaba, Zelal; Ramakrishnan, Rakhee K.; Askari, Narjes Saheb Sharif; Salameh, Laila; Alhariri, Hassan; Vats, Mayank; Erabia, Wafa Taleb; Alshawamreh, Esra'a Mohammad; Alfoteih, Yassen; Mogas, Andrea; Halwani, Rabih; Hamid, Qutayba

doi:10.4103/atm.atm_37_22

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…A case-control study in 2022 demonstrated CPAP’s suppressive effect on pro-inflammatory cytokines in asthmatic patients with sleep apnea. 50 Well-designed studies are needed to understand the mutual impact and optimal treatment for asthma and OSA. 21 Table 1 presents a comprehensive list of treatment options along with their respective impacts on each disorder.…”

Section: Treatment Implicationsmentioning

confidence: 99%

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Asthma and obstructive sleep apnea: Unveiling correlations and treatable traits for comprehensive care

Pardo-Manrique,

Ibarra-Enríquez,

Serrano

et al. 2024

Chron Respir Dis

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Asthma and obstructive sleep apnea (OSA) are common respiratory disorders. They share characteristics such as airway obstruction, poor sleep quality, and low quality of life. They are often present as comorbidities, along with obesity, gastroesophageal reflux disease (GERD), and allergic rhinitis (AR), which impacts the disease’s control. In recent years, there has been discussion about the association between these conditions and their pathophysiological and clinical consequences, resulting in worse health outcomes, increased healthcare resource consumption, prolonged hospital stays, and increased morbidity and mortality. Some studies demonstrate that treatment with continuous positive airway pressure (CPAP) can have a beneficial effect on both pathologies. This review summarizes the existing evidence of the association between asthma and OSA at their pathophysiological, epidemiological, clinical, and therapeutic levels. It intends to raise awareness among healthcare professionals about these conditions and the need for further research.

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Section: Treatment Implicationsmentioning

confidence: 99%

“…A study recommends using the Stop-Bang questionnaire for early detection of sleep apnea in asthmatic patients. 5 , 50 Physicians should diagnose and treat sleep apnea in asthma patients to delay airway remodeling and prevent lung function deterioration. 18 …”

Section: Treatment Implicationsmentioning

confidence: 99%