Continuous Petri Nets: Controllability and Control

Júlvez, Jorge; Vázquez, Carlos; Mahulea, Cristian; Silva, Manuel

doi:10.1007/978-1-4471-4276-8_20

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Controllability is a topic explored for many types of networks, including Petri nets, see [55]. Their potential in the context of biological or biomedical applications such as those in [56], remains to be explored, along similar lines as those explored in this paper.…”

Section: Discussionmentioning

confidence: 85%

Network Controllability Analysis of Three Multiple-myeloma Patient Genetic Mutation Datasets

Martin

Petre

2020

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Network controllability focuses on the concept of driving the dynamical system associated to a directed network of interactions from an arbitrary initial state to an arbitrary final state, through a well-chosen set of input functions applied in a minimal number of so-called input nodes. In earlier studies we and other groups demonstrated the potential of applying this concept in medicine. A directed network of interactions may be built around the main known drivers of the disease being studied, and then analysed to identify combinations of drug targets controlling survivability-essential genes in the network. This paper takes the next step and focuses on patient data. We demonstrate that comprehensive protein-protein interaction networks can be built around patient genetic data, and that network controllability can be used to identify possible personalised drug combinations. We discuss the algorithmic methods that can be used to construct and analyse these networks.

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Section: Discussionmentioning

confidence: 85%

Network Controllability Analysis of Three Multiple-myeloma Patient Genetic Mutation Datasets

Martin

Petre

2020

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“…This discrete event control verification process, accepted by the international community (David & Alla, 2010;Miyagui, 1996;Murata, 1989;Ramadge & Wonham, 1989), is applicable in the GHENeSys methodology because it encapsulates the small continuous parts within the discrete model in macroelements, which represents an advantage concerning the discrete ones (Miyagui, 1996;Ramadge & Wonham, 1989;Raman & Sreenivas, 2021), which do not allow studying the efficiency of integration. It also has an advantage over totally continuous methods (Åström et al, 1996;David & Alla, 2010;Júlvez et al, 2013;Ogata, 2010) because macroelements encapsulate continuous part, and it is not necessary to increase the complexity of the network integrated to a fluidized Petri net (David & Alla, 2010;Hermosilla et al, 2021;Júlvez et al, 2013) with more complex verification algorithms.…”

Section: Resultsmentioning

confidence: 99%

Design of an Integrated Automation & Control System Using Petri Nets: Case Study

Núñez-Alvarez,

Benítez-Pina,

Acosta-Montoya

et al. 2023

JART

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El Sistema de Control y Automatización Integrado (IACS) basado en el control de eventos discretos mediante redes de Petri (PN) que abarca el diseño, análisis y validación de modelos de sistemas de bombeo industrial no se utilizan comúnmente. Nuestro caso de estudio es el diseño e implementación de un sistema de supervisión utilizando el software GHENeSys PN y EROS en la Estación de Bombeo "San Juan" en Santiago de Cuba, Cuba. Estas herramientas permiten describir los modelos de los estados del proceso automático local y el funcionamiento del Supervisor, para tener en cuenta, las funciones de Mantenimiento Preventivo y Tratamiento de Alarmas. El IACS parte de la simulación MatLab de los lazos de control principales y utiliza la red jerárquica extendida GHENeSys para modelar un sistema de automatización integrado estructurado modularmente que responde a las demandas funcionales sincronizadas. Esta metodología tiene las ventajas de una modularidad jerárquica completa desde el control local hasta la gestión de producción, varias herramientas modulares de verificación y validación y compatibilidad total con IEC61131. Esto reduce los errores de diseño y el tiempo de implementación con una mayor eficiencia de integración.

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Half a century after Carl Adam Petri’s Ph.D. thesis: A perspective on the field

Silva

2013

Annual Reviews in Control

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Continuous Petri Nets: Controllability and Control

Cited by 5 publications

References 23 publications

Network Controllability Analysis of Three Multiple-myeloma Patient Genetic Mutation Datasets

Network Controllability Analysis of Three Multiple-myeloma Patient Genetic Mutation Datasets

Design of an Integrated Automation & Control System Using Petri Nets: Case Study

Half a century after Carl Adam Petri’s Ph.D. thesis: A perspective on the field

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