Continuous Peritoneal Dialysis

Mion, C

doi:10.1007/978-0-585-36947-1_23

Cited by 4 publications

(1 citation statement)

References 326 publications

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“…Continuous ambulatory peritoneal dialysis (CAPD) is known to normalize blood pressure (BP) (1,2), but it may also lead to systemic or orthostatic hypotension (2,3). Liberalization of intake and/or administration of salt are proposed treatments (4).…”

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Hypotension on CAPD: Can use of Vasoconstrictive Drugs be Harmful?

et al. 2002

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mentioning

confidence: 99%

Hypotension on CAPD: Can use of Vasoconstrictive Drugs be Harmful?

et al. 2002

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Artificial Kidney, Modeling of Transport Phenomena in

Eloot

Verdonck

2006

Wiley Encyclopedia of Biomedical Engineering

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Patients suffering from renal failure can be treated with a renal replacement therapy. Although a possible transplantation is determined by the availability of kidney donors, peritoneal dialysis is only adequate for patients with sufficient remaining renal function. As a third alternative, hemodialysis therapy can be used in which the patient's blood is purified extracorporeally in a hemodialyzer. To have better insight in this blood purification modality, dialyzer geometry, membrane properties, fluid characteristics, and the basic transport phenomena are described. Focused on a hollow fiber dialyzer, an overview is given of models and experiments describing blood and dialysate flow on a macroscopic basis. Also, the physical models handling of microscopic phenomena like concentration polarization and mass transport are described. Finally, in‐house developed CFD (computational fluid dynamics) and experimental models are presented, which aim at optimizing dialyzer geometry by looking more in detail at transport processes and fluid properties inside the dialyzer. First, a macroscopic CFD model to visualize blood and dialysate flow distributions was developed and validated using SPECT (single‐photon emission‐computed tomography) medical imaging. Second, a microscopic numerical model was developed to describe flow and mass transport in a single dialyzer fiber. After model calibration and validation, the impact on solute removal of a variable fiber length and diameter was assessed for small and middle molecules. Also, the model was used to examine the effect of flow maldistribution by implementing the experimental SPECT results.

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Liver Cell Reactive Components in Peritoneal Dialysis Fluids

Riegel

Ulrich

Friedrichsohn

et al. 1999

Mineral Electrolyte Metab

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Metabolic changes in peritoneal dialysis (PD) patients are an important aspect concerning long-term outcome. Liver plays the main role in regulating metabolism. The effects of peritoneal dialysis fluids (PDF) on liver cell function are scarcely investigated. Therefore, we investigated the effects of PDF, different in some components, on liver cell metabolism in vitro. Metabolic activity (MTT), cell integrity (LDH release), proliferation (BrdU incorporation) and synthesis of albumin and transferrin are measured by incubating HepG2 cells for 3 h and 24 h with six different PDFs: (a) lactate-buffered, pH5.5: PDF I (1.5% gluc.); PDF II (4.5% gluc.); (b) bicarbonate-buffered, pH7.4: PDF III (1.5% gluc.), PDF IV (4.5% gluc.); (c) amino acid-based solutions, pH 7.4: PDF V (low AA level) and PDF VI (high AA level). Metabolic activity of bicarbonate-treated cells is greatly enhanced in comparison to lactate-buffered PDFs. These findings are confirmed by proliferation data. Synthesis of albumin and transferrin is significantly enhanced by amino acid-based solutions. Our data demonstrate, that lactate-buffered PDF impair liver cells much stronger than bicarbonate-buffered PDF. pH is the parameter which contributes to cytotoxicity and impaired metabolism to a major extent. In contrast to glucose-containing solutions, amino acid-based PDF stimulate protein synthesis in liver cells.

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Continuous Peritoneal Dialysis

Cited by 4 publications

References 326 publications

Hypotension on CAPD: Can use of Vasoconstrictive Drugs be Harmful?

Hypotension on CAPD: Can use of Vasoconstrictive Drugs be Harmful?

Artificial Kidney, Modeling of Transport Phenomena in

Liver Cell Reactive Components in Peritoneal Dialysis Fluids

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