Continuous Online Titer Monitoring in CHO Cell Culture Supernatant Using a Herringbone Nanofluidic Filter Array
Zhumei Rohskopf,
Taehong Kwon,
Sung Hee Ko
et al.
Abstract:Online monitoring of monoclonal antibody product titers
throughout
biologics process development and production enables rapid bioprocess
decision-making and process optimization. Conventional analytical
methods, including high-performance liquid chromatography and turbidimetry,
typically require interfacing with an automated sampling system capable
of online sampling and fractionation, which suffers from increased
cost, a higher risk of failure, and a higher mechanical complexity
of the system. In this study, … Show more
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