Regression equations have many useful roles in neuropsychological assessment. This article is based on the premise that there is a large reservoir of published data that could be used to build regression equations; these equations could then be used to test a wide variety of hypotheses concerning the functioning of individual cases. This resource is currently underused because (a) not all neuropsychologists are aware that equations can be built with only basic summary data for a sample and (b) the computations involved are tedious and prone to error. To overcome these barriers, the authors set out the steps required to build regression equations from sample summary statistics and the further steps required to compute the associated statistics for drawing inferences concerning an individual case. The authors also develop, describe, and make available computer programs that implement the methods. Although caveats attach to the use of the methods, these need to be balanced against pragmatic considerations and against the alternative of either entirely ignoring a pertinent data set or using it informally to provide a clinical "guesstimate."Keywords: neuropsychological assessment, regression equations, single-case methods Regression equations serve a number of useful functions in the neuropsychological assessment of individuals (Chelune, 2003;Crawford, 2004;Crawford & Howell, 1998;Strauss, Sherman, & Spreen, 2006;Temkin, Heaton, Grant, & Dikmen, 1999). For example, they are widely used to estimate premorbid levels of ability in clinical populations by using psychological tests that are relatively resistant to neurological or psychiatric dysfunction (Crawford, 2004;Franzen, Burgess, & Smith-Seemiller, 1997;O'Carroll, 1995).Another common application of regression is in the assessment of change in neuropsychological functioning in the individual case. Here a regression equation can be built (usually by using healthy participants) to predict a patient's level of performance on a cognitive ability measure at retest from their score at initial testing. An obtained retest score that is markedly lower than the predicted score suggests cognitive deterioration (Crawford, 2004;Heaton & Marcotte, 2000;Sherman et al., 2003;Temkin et al., 1999).Clinical samples can also profitably be used to build regression equations for predicting retest scores. For example, Chelune, Naugle, Lüders, Sedlak, and Awad (1993) built an equation to predict memory scores at retest from baseline scores in a sample of temporal lobe epilepsy cases who had not undergone any surgical intervention in the intervening period. The equation was then used to assess the effects of surgery on memory functioning in further individual patients.Regardless of whether the equation was built from a healthy or clinical sample, this approach simultaneously factors in the strength of correlation between scores at test and retest (the higher the correlation the smaller the expected discrepancies), the effects of practice (typically scores will be higher on retest), and reg...