Continuous Noninvasive Glucose Monitoring Technology Based on “Occlusion Spectroscopy”

Abstract

This study indicates the potential use of OrSense's NBM device as a noninvasive sensor for continuous blood glucose evaluation. The device was safe and well tolerated.

Glucose sensors: a review of current and emerging technology

“…A clinical study showed a mean absolute relative difference of 17.2 and 95.5% of values in zones A and B of the Clarke error grid [46].…”

Recent developments in minimally and truly non-invasive blood glucose monitoring techniques

“…A small implantable fluorescence-based sensor combined with a body-worn data transmitter was proposed in [9] to increase the sensor lifetime up to 6 months comparing to a few weeks' lifetime of typical subcutaneous sensors. A watch-type transdermal sensor using microneedles to extract ISF glucose through skin [10], an ultrasound and multi-sensor-based ear-clip type non-invasive sensor for discrete measurement [11], a contact-lens-type noninvasive sensor measuring glucose concentration in tears [12], an occlusion spectroscopy-based sensor measuring blood flow [13], and electrochemical subcutaneous continuous monitoring sensors [14] have been reported. A sensor based on the combination of impedance (10 to 76 kHz range) and multiwavelength (850nm, 950nm, 1300nm) near infra-red (NIR) spectroscopy with a dedicated integrated circuit [15] and a technique measuring the refraction of visible laser light to overcome the signal to noise ratio issue related to NIR spectroscopy [16] were also reported.…”

Continuous glucose monitoring systems in the service of artificial pancreas

“…It is suitable solution for measuring the general state (quantity and quality) of blood because it can measure the property of blood particles, like red blood cells (RBC). Investigating the scatter pattern of RBC aggregation at the site the glucose concentration can be evaluated [40]. The principle of scattering spectroscopy is the same as occlusion spectroscopy.…”