Continuous Microfiber Wire Mandrel‐Less Biofabrication for Soft Tissue Engineering Applications (Adv. Healthcare Mater. 13/2022)

Adamo, Arianna; Bartolacci, Joseph; Pedersen, Drake D.; Traina, Marco G.; Kim, Seungil; Pantano, Antonio; Ghersi, Giulio; Watkins, Simon C.; Wagner, William R.; Badylak, Stephen F.; D’Amore, Antonio

doi:10.1002/adhm.202270075

Cited by 1 publication

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“…[1] This leads to modulusmismatch at the interface, inducing failure mechanisms where tissues are torn. [2][3][4][5] Viscous surgical adhesives address this DOI: 10.1002/adhm.202303666 limitation through stress distribution with less risk of soft tissue fracture. Other beneficial attributes include a gentler learning curve and less stringent working environment.…”

Section: Introductionmentioning

confidence: 99%

Tougher Bioadhesives through Dual Stimulation Strategies

Ang,

Djordjevic,

Solic

et al. 2024

Adv Healthcare Materials

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Carbene based bioadhesives have favourable attributes for tissue adhesion, including non‐specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene‐precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal‐rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via 19F NMR. The latter exploits the sensitive ‐CF3 functional group to determine joule‐based light/temperature kinetics on trifluoroaryl diazirine consumption. The combination of heat and photoactivation produced bioadhesives that are 3x tougher compared to control. Dual thermal/light irradiation may be a strategy to improve viscoelastic dissipation and toughness of photo‐activated adhesive resins.This article is protected by copyright. All rights reserved

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