Continuous metronomic temozolamide with propranolol and etodolac in recurrent globlastoma: A pilot study.

Bhattacharyya, Gouri Shankar; Ranade, Anantbhushan; Malhotra, Hemant; Babu, K Govind; Shahid, T.; Parikh, Purvish M.; Bascomb, Newell F.; Chanda, Amitabha

doi:10.1200/jco.2014.32.15_suppl.e13005

Cited by 2 publications

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“…Bhattacharyya et al reported on the use of the combination of metronomic temozolomide (mTMZ), the COX-2 inhibitor etodolac and PRO in recurrent glioblastoma at ASCO 2014 [83]. A series of 32 patients were randomised to either mTMZ or mTMZ with VT-122 (the combination of PRO 20 mg BID and etodolac 400 mg BID).…”

Section: Human Datamentioning

confidence: 99%

Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

Pantziarka

Bouche

Sukhatme³

et al. 2016

ecancer

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Propranolol (PRO) is a well-known and widely used non-selective beta-adrenergic receptor antagonist (beta-blocker), with a range of actions which are of interest in an oncological context. PRO displays effects on cellular proliferation and invasion, on the immune system, on the angiogenic cascade, and on tumour cell sensitivity to existing treatments. Both pre-clinical and clinical evidence of these effects, in multiple cancer types, is assessed and summarised and relevant mechanisms of action outlined. In particular there is evidence that PRO is effective at multiple points in the metastatic cascade, particularly in the context of the post-surgical wound response. Based on this evidence the case is made for further clinical investigation of the anticancer effects of PRO, particularly in combination with other agents. A number of trials are on-going, in different treatment settings for various cancers.

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Section: Human Datamentioning

confidence: 99%

Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

Pantziarka

Bouche

Sukhatme³

et al. 2016

ecancer

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“…Preliminary results of an ongoing clinical study suggest that propranolol in combination with etodolac (VT-122) might have a positive effect on survival in recurrent glioblastoma patients. Hypothetically, VT-122 attenuates inflammation and thereby increases tolerability for anticancer therapy [51,52]. Additionally, including medication and beta-blocker usage in large prospective neurooncological registries could be valuable in investigating the effect on cancer-related patient outcomes.…”

Section: Future Researchmentioning

confidence: 99%

Beta-blockers and glioma: a systematic review of preclinical studies and clinical results

et al. 2020

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Given the median survival of 15 months after diagnosis, novel treatment strategies are needed for glioblastoma. Beta-blockers have been demonstrated to inhibit angiogenesis and tumor cell proliferation in various cancer types. The aim of this study was to systematically review the evidence on the effect of beta-blockers on glioma growth. A systematic literature search was performed in the PubMed, Embase, Google Scholar, Web of Science, and Cochrane Central to identify all relevant studies. Preclinical studies concerning the pharmacodynamic effects of beta-blockers on glioma growth and proliferation were included, as well as clinical studies that studied the effect of beta-blockers on patient outcomes according to PRISMA guidelines. Among the 980 citations, 10 preclinical studies and 1 clinical study were included after title/abstract and full-text screening. The following potential mechanisms were identified: reduction of glioma cell proliferation (n = 9), decrease of glioma cell migration (n = 2), increase of drug sensitivity (n = 1), induction of glioma cell death (n = 1). Beta-blockers affect glioma proliferation by inducing a brief reduction of cAMP and a temporary cell cycle arrest in vitro. Contrasting results were observed concerning glioma cell migration. The identified clinical study did not find an association between beta-blockers and survival in glioma patients. Although preclinical studies provide scarce evidence for the use of beta-blockers in glioma, they identified potential pathways for targeting glioma. Future studies are needed to clarify the effect of beta-blockers on clinical endpoints including survival outcomes in glioma patients to scrutinize the value of beta-blockers in glioma care.

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Continuous metronomic temozolamide with propranolol and etodolac in recurrent globlastoma: A pilot study.

Cited by 2 publications

References 0 publications

Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

Beta-blockers and glioma: a systematic review of preclinical studies and clinical results

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