Continuous low surface tension and high viscosity two phases liquid separation

Wang, Xi-Lun; Ni, Can-Hong; Chang, Junwei; Chiang, Ya-Yu

doi:10.1016/j.snb.2022.131957

Cited by 3 publications

(9 citation statements)

References 38 publications

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“…The organic phase (usually a carrier liquid), which has lower air–liquid interfacial tension than the aqueous phase, preferentially wets the wire and is accumulated in the wire. The organic phase subsequently drips out of the wire due to the continuous incoming flow, resulting in a decreasing distance between the aqueous droplets and causing them to merge inside the helix wire . The merged aqueous droplets eventually form a continuous cylindrical stream, are radially encircled by air, and flow toward the glass cavity outlet #1.…”

Section: Design Theorymentioning

confidence: 99%

“…The organic phase subsequently drips out of the wire due to the continuous incoming flow, resulting in a decreasing distance between the aqueous droplets and causing them to merge inside the helix wire. 1 The merged aqueous droplets eventually form a continuous cylindrical stream, are radially encircled by air, and flow toward the glass cavity outlet #1. The dripped organic droplets are collected at outlet #2 (Figure 1A).…”

Section: Design Theorymentioning

confidence: 99%

“…Biphasic liquid systems are frequently observed in pipe flows in the petrochemical, pharmaceutical, energy, and healthcare industries. Two-phase flow separation is a key step in the downstream process in which a stream containing target compounds is separated − into two streams. The separation efficiency directly affects the product purity and cost.…”

Section: Introductionmentioning

confidence: 99%

“…This study presents an aqueous–organic–air interface control core-annular separator for biphasic flow separation and two machine learning-based methods for process prediction. A core-annular separator has a simple geometric configuration and can easily maintain a steady-state separation process. , The separator is connected immediately after a droplet reactor. The separator has an adjustable structure to adapt to various interfacial tensions and enables separation processes for the separation of four liquid pairs.…”

Section: Introductionmentioning

confidence: 99%

“…A core-annular separator has a simple geometric configuration and can easily maintain a steady-state separation process. 1,25 The separator is connected immediately after a droplet reactor. The separator has an adjustable structure to adapt to various interfacial tensions and enables separation processes for the separation of four liquid pairs.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator

Chang

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Two-phase flow separation is a key step in various downstream purification processes. The use of a separator with controllable flow behavior is recommended to avoid contamination. In this study, a core-annular separator for biphasic flow separation with four different chemical polarities was developed, and two machine learning-based methods were proposed for answering two emergent questions to meet real industrial needs. (1) Could complete two-phase separation be achieved under these operating conditions? (2) Could the separation process be accelerated by determining the maximum input flow rate of the water? Process prediction for automation, machine learning-based classifiers, and multilayer perceptron were used to address these questions by predicting successful separation and the maximum input flow rates of unknown water−solvent systems with limited experimental data as training samples. The core-annular separator achieved complete two-phase water−solvent separation at a maximum total input flow rate of 4000 μL min −1 . Moreover, the classification accuracy for complete separation reached 92.2%, and the multilayer perceptron network had the best performance for predicting the flow rate. This liquid−liquid interface manipulation separator and machine learning method could decrease the cost of relevant process development.

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Section: Design Theorymentioning

confidence: 99%

Section: Design Theorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator

Chang

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Performance of different microfluidic devices in continuous liquid-liquid separation

Oldach,

Chiang,

Ben-Achour

et al. 2024

J Flow Chem

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Droplet-based microfluidics exhibit numerous benefits leading to relevant innovations and many applications in various fields. The precise handling of droplets in capillaries, including droplet formation, manipulation, and separation, is essential for successful operation. Only a few reports are known concerning the separation of segmented flows, particularly the continuous separation of droplets, which is of high interest regarding the control of biochemical and chemical reactions or other applications where the contact time of the involved phases is crucial. Here, the separation must be flexible and adjusted to different flow parameters, such as the surface tension, the volumetric flow rates, and their ratios. This contribution presents two novel open-source approaches based on additive manufacturing and mechanical deforming for continuous liquid–liquid separation under various flow conditions. The Laplace pressure is the driving force for the separation, which is adjusted to the flow conditions by adapting the distance of pinning points provided by the design of the devices. Details of the device design and experimental setup are shown along with limitations to promote further development and to increase availability for researchers. With the right parameters, sophisticated separations can be realized by inexpensive laboratory equipment and simple control of them. It was found that the distance between the pinning points needs to enlarged for increasing volumetric flow rates and reduced for higher viscosities of the continuous phase respectively higher amounts of the dispersed phase. The open source approach of this article expands the exploration space in addition to commercially available phase separators only available to a selected group of people. Graphical Abstract

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Continuous high viscosity biphasic liquid separation

Chen,

Hsueh,

et al. 2024

Separation and Purification Technology

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Continuous low surface tension and high viscosity two phases liquid separation

Cited by 3 publications

References 38 publications

Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator

Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator

Performance of different microfluidic devices in continuous liquid-liquid separation

Continuous high viscosity biphasic liquid separation

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