Continuous liquid chromatography

Szepesy, L.; Sebestyén, Zs.; Feher, I.; Nagy, Z.

doi:10.1016/s0021-9673(00)84671-3

Cited by 20 publications

(5 citation statements)

References 7 publications

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“…Product purities were in excess of 99.9%. A 12-column configuration was also employed by Szepesy et al (1975) for recovery of benzene from gasoline and separation of C,6-C22 fatty esters. A similar system Vol.…”

Section: Aiche Journalmentioning

confidence: 99%

Design and performance of a simulated countercurrent moving‐bed separator

1993

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The design, construction and isothermal (298 K ) operation of a continuous flow simulated countercurrent moving-bed chromatographic separator for the gas-solid separation of binary mixtures is reported. It consists of only four packed columns, with countercurrency simulated by advancing the feedpoint from column to column in the direction of gas flow. The separated components have periodic concentration profiles, with a duty cycle that depends on operating parameters, and concentrations greater than in the feed stream. Test mixtures of propylene and dimethyl ether, which have retention times differing by a factor of 2 on the 60/80 mesh Chromosorb 101 packing, were successfully separated. Optimum feed advancement intervals and maximum product purity were experimentally determined as a function of feed rate. At low feed rates, when the adsorption isotherm is nearly linear, dimethyl ether was nearly completely separated from propylene, but propylene was found to contain varying amounts of dimethyl ether due to the effects of a nonlinear isotherm and heterogeneous adsorption.

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Section: Aiche Journalmentioning

confidence: 99%

Design and performance of a simulated countercurrent moving‐bed separator

1993

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“…This final class of separators uses multiple desorbent carrier streams. One liquid product stream is completely removed at one port, and the other product is removed with an isolated carrier stream (Barker, 1971;Barker and Critcher, 1960;Barker and Deeble, 1973;Barker and Abusabah, 1985;Barker et al, 1978Barker et al, , 1983Barker et al, , 1990Ruthven, 1985a,b, 1986;Ching et al, 1987Ching et al, , 1988Ching et al, , 1991Hashimoto et al, 1983aHashimoto et al, ,b, 1987Hashimoto et al, , 1989Hashimoto et al, , 1990aKishihara et al, 1989;Maki et al, 1987;Ruthven, 1984;Ruthven and Ching, 1989;Szepesy et al, 1975). These systems are also subdivided into four zones with multiple columns (ranging between two and six) per section.…”

Section: Multiple-desorbent Simulated-countercurrent Processesmentioning

confidence: 99%

Experimental evaluation of designs for the simulated countercurrent moving bed separator

Tonkovich

Carr

1996

AIChE Journal

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Simulated countercutrent chromatography is a continuous flow method for separation of binary mixtures or for separation of multicomponent mixtures into two fractions. Countercurrent jlow is simulated by moving the feed point past several f i e d adsorbent beds at a rate between the single column breakthrough time of each component. The number of columns and the location of the inlet and outlet port were vaned to inuestigate product purity and productiviy. Concentration profiles of the efluent product streams were measured. The maximum product concentration exceeds the feed concentration during part of the feed-switching cycle and drops to zero duringpart of the cycle. Three configurations were tested with the total number of columns valying between three and eight. For the test separation chosen, gaseous propylene and dimethyl ether on Chromosorb 101, high purity (> 99%) product streams were obtained with an optimal four-column configuration using three desorbent streams.

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“…However, such a process scheme is obviously impractical and expensive. Multicomponent separation using a single unit of the simulated countercurrent apparatus was apparently first proposed by Szepesy et al (1975). The idea, however, was not pursued until Hashimoto et al (1993) reported a simulated countercurrent process which can resolve a three-component mixture into its individual components.…”

Section: Alche Journalmentioning

confidence: 99%

Multicomponent separation using a column‐switching chromatographic method

1994

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A cyclic chromatographic process based on the method of column switching was used to separate a three-component carbohydrate mixture. It permits continuous introduction of the feed and is designed to produce higher product concentration compared to a normal elution cyclic process. A fixed-bed model incorporating axial dispersion and a linear driving force for mass transfer was successfully used to estimate optimum operating conditions (switch times and fluid-flow rates). Its experimental setup can be easily constructed by modifying the apparatus of a simulated countercurrent process since both systems comprise segmented columns equipped with on-off valves for fluid-flow control. This allows one to conduct either multicomponent separation based on elution operation or binary separation based on countercurrent operation using essentially the same set of experimental apparatus with minor modification.

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Continuous liquid chromatography

Cited by 20 publications

References 7 publications

Design and performance of a simulated countercurrent moving‐bed separator

Design and performance of a simulated countercurrent moving‐bed separator

Experimental evaluation of designs for the simulated countercurrent moving bed separator

Multicomponent separation using a column‐switching chromatographic method

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