Continuous Intrathecal Administration of 5-Fluoro-2′-deoxyuridine for the Treatment of Neoplastic Meningitis

Abstract

This therapy may be useful, especially as a maintenance therapy for NM.

Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer

“…2a & b). This was consistent with the observation that most endogenous compounds exhibit a bell-shaped dose response relationship in normal cells when applied exogenously [20][21][22]. Cell proliferation response to S1P was also bell-shaped in the MCF7 cells with maximum stimulation obtained at 0.5 μM (Fig.…”

Breaking the Invulnerability of Cancer Stem Cells: Two-Step Strategy to Kill the Stem-like Cell Subpopulation of Multiple Myeloma

“…The fluoropyrymidine exhibits selective tumor toxicity due to the preferential metabolic activation by tumor cells (27). Clinically, bolus administration of FdUrd in patient with meningeal dissemination of malignant tumors was well-tolerated also at high doses (28,29). Evaluation of the results showed a favorable antitumor effect paired with apparently no adverse affects.…”

Neoplastic Meningitis from Solid Tumors: New Diagnostic and Therapeutic Approaches

“…The role of continuous i.t. 5-fluoro-2Ј-deoxyuridine (FdUrd) against solid tumor NM was investigated by Nakagawa et al [45] in a phase I study. They treated 25 patients with 0.5-1 g per day of i.t.…”