Continuous intra‐arterial chemotherapy for downstaging locally advanced oral commissure carcinoma

Abstract

Our data demonstrate that continuous IA chemotherapy could achieve a competitive acceptable survival rate and improved locoregional control of advanced oral commissure cancer.

Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study

“…Since cSCC is generally located in the facial region, surgery can occasionally cause unacceptable morpho‐functional results. In these cases, radiotherapy and systemic or intra‐arterial chemotherapy are alternative treatments. Therefore, the use of intralesional agents such as 5‐FU or Interferon α‐2b has been described.…”

Therapeutic Options in Unresectable Oral Squamous Cell Carcinoma: A Systematic Review

“…Two studies 31 , 47 evaluated the use of CT, one of them was a controlled clinical trial, 47 and another was an observational retrospective study. 31 One study 47 included 21 participants in the intervention group, whereas the other study 31 included just 8 people in the intervention group. All two studies 31 , 47 focused on patients with clinical stage III/IV oral cancer.…”

“… 31 One study 47 included 21 participants in the intervention group, whereas the other study 31 included just 8 people in the intervention group. All two studies 31 , 47 focused on patients with clinical stage III/IV oral cancer.…”

“…Wu 47 aimed to assess the efficacy of intra-arterial infusion CT for patients with locally advanced oral cancer. Patients received continuously an infusion of methotrexate (50 mg/day) into the external carotid artery for 8 days, followed by a weekly intra-arterial bolus of 25 mg methotrexate for 10 weeks.…”

Complete response of huge buccal malignant melanoma in an octogenarian patient to arterial chemotherapy

“…Intra‐arterial chemotherapy has been used in the context of neoadjuvant treatment with the rationale being to inhibit local tumor growth, thereby potentially reducing the local relapse rate and minimizing tumor cell spreading during subsequent operations . Intra‐arterial infusion chemotherapy was used for regional oral cancer treatment and resulted in good local tumor control by the superselective catheterization . Intra‐arterial chemotherapy theoretically is more beneficial than systemic chemotherapy in that higher concentrations of cytotoxic agents can be delivered to the tumor site with reduced systemic toxicity.…”