2008
DOI: 10.1002/14651858.cd006071.pub2
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Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants

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Cited by 29 publications
(14 citation statements)
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“…In addition, the effects of indomethacin on CBF appear to be dependent on the infusion rate. The 30-min infusion protocol used in the current study was based on a recent Cochrane review that recommended this duration to reduce perfusion effects without any loss of efficacy (28). The 18% reduction in CBF would appear to be in good agreement with the range of perfusion changes reported in previous studies using different infusion protocols.…”
Section: Indomethacin Effects On Brain Metabolismsupporting
confidence: 55%
“…In addition, the effects of indomethacin on CBF appear to be dependent on the infusion rate. The 30-min infusion protocol used in the current study was based on a recent Cochrane review that recommended this duration to reduce perfusion effects without any loss of efficacy (28). The 18% reduction in CBF would appear to be in good agreement with the range of perfusion changes reported in previous studies using different infusion protocols.…”
Section: Indomethacin Effects On Brain Metabolismsupporting
confidence: 55%
“…Reduction in cerebral, mesenteric and renal blood flow, spontaneous intestinal perforation, as well as platelet dysfunction are recognized as potential adverse effects of indomethacin treatment, and are partially overcome by continuous administration of the drug (17). …”
Section: Anti-inflammatory Treatmentmentioning
confidence: 99%
“…Intravenous indomethacin is usually given as bolus over 30 min, only two small trials compared continuous with intermittent bolus administration and reported no statistically significant differences in PDA closure at day 2 or day 5, rates of reopening of PDA, neonatal mortality, IVH, and NEC [130]. …”
Section: How To Treat?mentioning
confidence: 99%