Continuous Infusion Epidural Analgesia in Parturients Receiving Bupivacaine, Chloroprocaine, or Lidocaine—Maternal, Fetal, and Neonatal Effects

Abboud, T. K.; Afrasiabi, A.; Sarkis, F.; Daftarian, F.; Nagappala, S.; Noueihed, R.; Kuhnert, Betty R.; Miller, Frank C.; Bassell, Gerard M.

doi:10.1097/00132582-198412000-00031

Cited by 14 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is concluded from our study that the NACS that has been used recently to evaluate neonatal effects of obstetric medications (15,(19)(20)(21) is a valid and sensitive examination for neurobehavioral Performance, and that general anesthesia for cesarean section is more depressant than regional anesthesia during the first few hours of life. Because these findings may have minimal effects on a healthy infant, a high risk neonate may be adversely affected by general anesthesia and further work is needed to evaluate the effect of general and regonal anesthesia on high risk neonates.…”

Section: Discussionmentioning

confidence: 79%

Comparison of the Effects of General and Regional Anesthesia for Cesarean Section on Neonatal Neurologic and Adaptive Capacity Scores

Abboud

Nagappala

Murakawa

et al. 1985

Anesthesia & Analgesia

View full text Add to dashboard Cite

YANAGI T, SHEIKH-OL-ESLAM A. Comparison of the effects of general and regional anesthesia for cesarean iiiitil d e l i z~r y of the baby. All ~iiotlzers were henlthy, not iiz /nbor, nrfd zoere sc/iedct/ed for e k t i v e cesarean section. All iicoiintcs iL'CigheCI 2500 g or more, had Apgar scores of 7 or more at 2 aiid 5 iiiiri, aiid had tzormal acid base and blood sas dntn. Netiiiafes delizwed with gmeraf anesthesia scored sipificaiitly lozcler oil some of the test items for adaptive section on neonatal neurologic and adaptive capacity scores. Anesth Analg 1985;63:996-1000. cnpacity, pflssiizle t o m , active tone, primary reflexes, and iotni scores nf t l o f h 75 rnirr and 2 hr of age (P < 0.051 fharz thosc dcliz~cred zoith either epidural or spinal anesthesia. Nroriizte.; rfelizvred with epidural anesthesia scored lower fhnii thow dclizwed with spinal aizesthesia on supporting reactioii urid motor activity nt 2 hr of age (P < 0.05). All iieoiintes hnd high scores at 24 hr, at which time there were i i o sipificaiit differewes betuleen the three groups.Fiftytwo iieoriates deliz~cred hy electi7~ cesnrenif sectioii i('c'rf' ezdunfed irsitig the Neoiiatnl Neurologic aiid Adaptizle Cnpacity Scores. Tzueiity of the rriothers receizlrd ~qerierol nr7csthcsia, 14 received epidural, a i d 18 rcceizled spiiinl oiicsthesin. All mothers rcccizliizg regioiznl arzesthesin ~L W C ~~ri~hydrated with 1000 1111 of hetoted Riii

show abstract

Section: Discussionmentioning

confidence: 79%

Comparison of the Effects of General and Regional Anesthesia for Cesarean Section on Neonatal Neurologic and Adaptive Capacity Scores

Abboud

Nagappala

Murakawa

et al. 1985

Anesthesia & Analgesia

View full text Add to dashboard Cite

show abstract

“…The search for reasons why decelerations increased after epidural anaesthesia raises the possibility of direct pharmacological side effects of the local anaesthetic on the fetus. Various authors could not establish any negative effects on the postpartal situation of the newborn, even when higher bupivacaine doses were used in caesarean sections [15,[17][18][19]. This could be interpreted as direct myocardial side effects of the local anaesthetic in the fetus.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal hypoxic acidosis can raise the UV/MV ratio of local anaesthetics and seems to potentiate the toxic effects of these 116 O R I G I N A L I E N substances [20]. However, neurophysiological examinations of infants whose mothers received epidural anaesthesia with bupivacaine during childbirth are normal whereas there is controversy about the effect of other local anaesthetics [17]. Meyer and coworkers [21] examined two fetuses after epidural anaesthesia with bupivacaine.…”

Section: Discussionmentioning

confidence: 99%

Changes in fetal heart rate patterns during epidural anaesthesia

Korebrits¹,

Santos²,

Brückner³

et al. 1999

PerinatalMedizin

View full text Add to dashboard Cite

“…Our EA infants in fact scored significantly lower than the GA infants on rooting at the agr of 3 h, improving significantly in this respect by the age of 1 day, and the tendency was the same with surking, although the difference was not significant, We used bupivacaine for the epidurals, whereas Abboud et al (5) used either chloroprocaine or lidocaine, a difference which becomes interesting in the light of the findings of Kileff et al (25) that infants born after caesarean section using bupivacaine EA scored .lower on sucking at the age of 24 h than those born after caesarean section using lidocaine EA. No other study using the Scanlon Early Neonatal Neurobehavioural Scale (7) or the Neurologic and Adaptive Capacity Scoring System (26) has demonstrated any adverse effects of bupivacaine on neurobehavioural responses (10,(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of general and epidural anaesthesia for caesarean section on the neurobehavioural responses of newborn infants

Kangas-Saarela

Koivisto

Jouppila

et al. 1989

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Thirty-one neonates delivered by elective caesarean section were evaluated at the ages of 3 h, 1 day, 2 days and 4-5 days using Scanlon's Early Neonatal Neurobehavioural Scale and tests for orientation. Thirteen of the mothers received general anaesthesia and 18 epidural anaesthesia. All the mothers were healthy and not in labour. All the neonates weighed 2500 g or more and had Apgar scores of 7 or more at 1, 5 and 15 min. The neonates delivered with epidural anaesthesia scored significantly lower on rooting at the age of 3 h than those delivered with general anaesthesia, but the latter scored significantly lower on habituation to sound and orientation to both animate and inanimate visual stimuli. General anaesthesia seemed to depress the infants' interactive processes (orientation items), and their ability to make an appropriate response to repetitive stimuli (habituation) more than did epidural anaesthesia, indicating greater global depression. This depression was short-lived, however, and there were no differences between the groups on any of the parameters after 24 h.

show abstract

Continuous Infusion Epidural Analgesia in Parturients Receiving Bupivacaine, Chloroprocaine, or Lidocaine—Maternal, Fetal, and Neonatal Effects

Cited by 14 publications

References 0 publications

Comparison of the Effects of General and Regional Anesthesia for Cesarean Section on Neonatal Neurologic and Adaptive Capacity Scores

Comparison of the Effects of General and Regional Anesthesia for Cesarean Section on Neonatal Neurologic and Adaptive Capacity Scores

Changes in fetal heart rate patterns during epidural anaesthesia

Comparison of the effects of general and epidural anaesthesia for caesarean section on the neurobehavioural responses of newborn infants

Contact Info

Product

Resources

About