Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Su Feng,
Ting Zhang,
Zhengxiao He
et al.
Abstract:Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive administration and whether immunosuppression can be withdrawn to mitigate side effects remain unclear. Human induced neural stem/progenitor cells (iNPCs) have shown long-term survival and efficient neuronal differentiation in primate brains. Here, we evaluate the immune responses in primate brains triggered by… Show more
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